• Publications
  • Influence
Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies.
TLDR
Voxel-based morphometry can be used as an exploratory whole-brain approach to identify abnormal brain regions in schizophrenia, which should then be validated by using region-of-interest analyses. Expand
Molecular pathology of schizophrenia: more than one disease process?
  • T. Crow
  • Medicine
  • British medical journal
  • 12 January 1980
TLDR
In Florence showed some symptomatic improvement with only minor side effects, but this requires confirmation in a controlled trial, and another approach is based on the finding that suppressor lymphocyte activity is depressed during acute relapses in multiple sclerosis. Expand
The two-syndrome concept: origins and current status.
  • T. Crow
  • Psychology, Medicine
  • Schizophrenia bulletin
  • 1985
The two-syndrome concept postulates two "dimensions of pathology" underlying schizophrenia--a reversible (and potentially neuroleptic-responsive) component and a sometimes progressive and relativelyExpand
Neuropeptide Y distribution in the rat brain.
TLDR
Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for Immunostaining of pancreatic polypeptides-like immunoreactivity in the mammalian brain. Expand
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
TLDR
It is shown here that PrP codon 102 is linked to the putative gene for the syndrome in two pedigrees, providing the best evidence to date that this familial condition is inherited despite also being infectious, and that substitution of leucine for proline at PrPcodon 102 may lead to the development of Gerstmann–Sträussler syndrome. Expand
Is schizophrenia the price that Homo sapiens pays for language?
  • T. Crow
  • Psychology, Medicine
  • Schizophrenia Research
  • 19 December 1997
TLDR
The significance of nuclear symptoms is that these reflect a breakdown of bi-hemispheric coordination of language, perhaps specifically of the process of 'indexicalisation' of self- versus other-generated references. Expand
Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species
  • T. Crow
  • Medicine, Psychology
  • Brain Research Reviews
  • 1 March 2000
TLDR
The hypothesis is proposed that the predisposition to schizophrenia is a component of Homo sapiens-specific variation associated with the capacity for language, reflected particularly in association cortex, from right frontal to left occipital. Expand
GENETIC AND ENVIRONMENTAL INFLUENCES
review the literature on handedness, dichotic listening and anatomical asymmetry in schizophrenia and concluded that there was strong evidence for decreased cerebral lateralisation. As they pointExpand
Relative hand skill predicts academic ability: global deficits at the point of hemispheric indecision
TLDR
Assessing relative hand skill as a predictor of verbal, non-verbal, and mathematical ability and reading comprehension at the age of 11 years found females performed better than males, but the relationship torelative hand skill was closely similar for the two sexes. Expand
Microduplications of 16p11.2 are Associated with Schizophrenia
TLDR
A meta-analysis of datasets for multiple psychiatric disorders showed a significant association of the microduplication with schizophrenia, bipolar disorder, and autism, while the reciprocal microdeletion was associated only with autism and developmental disorders. Expand
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