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Chromosome territories, nuclear architecture and gene regulation in mammalian cells
The expression of genes is regulated at many levels. Perhaps the area in which least is known is how nuclear organization influences gene expression. Studies of higher-order chromatin arrangementsExpand
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Dynamics of DNA Replication Factories in Living Cells
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in the nucleus. These foci consist of DNA associated with replication machineries, i.e., large proteinExpand
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Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes
Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cellExpand
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Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional architecture found inExpand
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Matrix‐based comparative genomic hybridization: Biochips to screen for genomic imbalances
Comparative genomic hybridization (CGH) to metaphase chromosomes has been widely used for the genome‐wide screening of genomic imbalances in tumor cells. Substitution of the chromosome targets by aExpand
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Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
The regulation of gene expression is mediated by interactions between chromatin and protein complexes. The importance of where and when these interactions take place in the nucleus is currently aExpand
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Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing
The preconditions and early steps of meiotic chromosome pairing were studied by fluorescence in situ hybridization (FISH) with chromosome- specific DNA probes to mouse and human testis tissueExpand
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Chromosome territories--a functional nuclear landscape.
Understanding nuclear architecture is indispensable for understanding the cell-type-dependent orchestration of active and silent genes and other nuclear functions, such as RNA splicing, DNAExpand
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Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells
A quantitative comparison of higher-order chromatin arrangements was performed in human cell types with three-dimensionally (3D) preserved, differently shaped nuclei. These cell types includedExpand
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Methyl CpG–binding proteins induce large-scale chromatin reorganization during terminal differentiation
Pericentric heterochromatin plays an important role in epigenetic gene regulation. We show that pericentric heterochromatin aggregates during myogenic differentiation. This clustering leads to theExpand
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