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Chromosome territories, nuclear architecture and gene regulation in mammalian cells
TLDR
The emerging view is that chromosomes are compartmentalized into discrete territories, and the location of a gene within a chromosome territory seems to influence its access to the machinery responsible for specific nuclear functions, such as transcription and splicing. Expand
Chromosome territories.
TLDR
Present knowledge of nonrandom CT arrangements, of the internal CT architecture, and of structural interactions with other CTs is provided as well as the dynamics of CT arrangements during cell cycle and postmitotic terminal differentiation. Expand
Dynamics of DNA Replication Factories in Living Cells
TLDR
Four dimensional analyses suggested that replication factories are stably anchored in the nucleus and that changes in the pattern occur through gradual, coordinated, but asynchronous, assembly and disassembly throughout S phase. Expand
Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes
TLDR
Modeling of 3D CT arrangements suggests that cell-type-specific differences in radial CT arrangements are not solely due to geometrical constraints that result from nuclear shape differences, and gene-density-correlated arrangements of higher-order chromatin shared by all human cell types studied so far are found. Expand
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
TLDR
It is shown that the nuclear architecture of rod photoreceptor cells differs fundamentally in nocturnal and diurnal mammals and suggests that the conventional architecture prevails in eukaryotic nuclei because it results in more flexible chromosome arrangements, facilitating positional regulation of nuclear functions. Expand
Initial Genomics of the Human Nucleolus
TLDR
Genomics of a nuclear compartment of the eukaryotic cell revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different gene families and certain satellite repeats as the major building blocks of NADs. Expand
Matrix‐based comparative genomic hybridization: Biochips to screen for genomic imbalances
TLDR
A protocol that allows CGH to chips consisting of glass slides with immobilized target DNAs arrayed in small spots to be developed, providing a basis for the development of automated diagnostic procedures with biochips designed to meet clinical needs. Expand
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
TLDR
This work has shown that the dynamic nature of the positioning of genetic material in the nuclear space and the higher-order architecture of the nucleus are integrated is essential to the overall understanding of gene regulation. Expand
The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.
TLDR
It is proposed that different lamins are organized into separate, but interacting, microdomains and that LB1 is essential for their organization and the organization and regulation of chromatin are influenced by interconnections between these laminmicrodomains. Expand
Chromosome territories--a functional nuclear landscape.
TLDR
This work has shown that chromosomes in the cell nucleus are organized as chromosome territories, and present models of chromosome territory architecture differ widely with respect to the possible functional implications of dynamic changes of this architecture during the cell cycle and terminal cell differentiation. Expand
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