Subclassification of the RBCC/TRIM Superfamily Reveals a Novel Motif Necessary for Microtubule Binding*
Binformatics investigation permitted subclassification of the entire human RBCC complement into nine subfamilies based on their varied C-terminal domain compositions, which may aid the understanding of the molecular function of members of each subgroup and their potential involvement in both basic cellular processes and human disease.
Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model
- N. Kaminen-Ahola, A. Ahola, S. Chong
- BiologyPLoS Genetics
- 1 January 2010
The work raises the possibility of a role for epigenetics in the etiology of fetal alcohol spectrum disorders, and it provides a mouse model that will be a useful resource in the continued efforts to understand the consequences of gestational alcohol exposure at the molecular level.
Microtia: Epidemiology and genetics
- D. Luquetti, C. Heike, A. Hing, M. Cunningham, T. Cox
- Medicine, BiologyAmerican Journal of Medical Genetics. Part A
- 1 January 2012
Current knowledge of the epidemiology and genetics of microtia is reviewed, including potential candidate genes supported by evidence from human syndromes and animal models, and the possible etiopathogenesis in light of the hypotheses formulated to date: Neural crest cells disturbance, vascular disruption, and altitude are discussed.
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome…
- K. Short, B. Hopwood, Zou Yi, T. Cox
- Biology, MedicineBMC Cell Biology
- 4 January 2002
These findings not only implicate Alpha 4 in the pathogenesis of Opitz GBBB syndrome but also support the earlier hypothesis that MID2 is a modifier of the X-linked phenotype.
New mutations in MID1 provide support for loss of function as the cause of X-linked Opitz syndrome.
- T. Cox, L. R. Allen, G. Suthers
- BiologyHuman Molecular Genetics
- 12 October 2000
It is shown that the MID1 gene spans at least 400 kb, almost twice the distance originally reported and has a minimum of six mRNA isoforms as a result of the alternative use of 5' untranslated exons, and the conclusion that X-linked OS results from loss of function of MID1 is supported.
Solution structure of the MID1 B-box2 CHC(D/C)C(2)H(2) zinc-binding domain: insights into an evolutionarily conserved RING fold.
- M. Massiah, J. Matts, T. Cox
- ChemistryJournal of Molecular Biology
- 25 May 2007
Molecular regulation of heme biosynthesis in higher vertebrates.
- B. May, S. Dogra, T. Sadlon, C. Bhasker, T. Cox, S. Bottomley
- BiologyProgress in Nucleic Acid Research and Molecular…
- 1995
Purifying natively folded proteins from inclusion bodies using sarkosyl, Triton X-100, and CHAPS.
- Hu Tao, Wenjun Liu, Brandi N Simmons, Helen K Harris, T. Cox, M. Massiah
- BiologyBioTechniques
- 2010
It is demonstrated for the first time that this combination of three detergents significantly improves binding efficiency of GST and GST fusion proteins to gluthathione (GSH) Sepharose.
Efficacy of sonic and ultrasonic activation for removal of calcium hydroxide from mesial canals of mandibular molars: a microtomographic study.
- Anne Wiseman, T. Cox, A. Paranjpe, N. M. Flake, N. Cohenca, James D. Johnson
- Medicine, Materials ScienceJournal of Endodontics
- 1 February 2011
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
- J. Drenckhahn, Q. Schwarz, T. Cox
- Biology, MedicineDevelopmental Cell
- 14 October 2008
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