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Evaluation of immunization with tachyzoite excreted-secreted proteins in a novel susceptible mouse model (A/Sn) for Toxoplasma gondii.
TLDR
Investigation of whether Toxoplasma gondii pooled excreted-secreted antigens (ESA), recovered from infected culture supernatants with tachyzoites used as immunogen, can protect experimental mice against T. Gondii infection suggested that immunized mice had lower parasitemia as well as longer survival than mice from the control group. Expand
Toxoplasma gondii: genotyping of strains from Brazilian AIDS patients with cerebral toxoplasmosis by multilocus PCR-RFLP markers.
TLDR
The sequencing of the nested-PCR products of type II and polymorphic isolates showed a nucleotide polymorphism compared with the archetypal clonal genotypes and these isolates were considered as polymorphic strains, confirming other studies showing the high rate of genetic polymorphism in T. gondii strains isolated in Brazil. Expand
Use of the serum reactivity against Toxoplasma gondii excreted-secreted antigens in cerebral toxoplasmosis diagnosis in human immunodeficiency virus-infected patients.
TLDR
The utility of ESA-ELISA in the diagnosis of cerebral toxoplasmosis in HIV-infected patients is suggested, since it provided clear evidence that anti-ESA antibodies are present principally in patients with active infection. Expand
Cerebral and ocular toxoplasmosis related with IFN-γ, TNF-α, and IL-10 levels
TLDR
The data suggest the low resistance to develop ocular lesions by the low ability to produce IFN-γ against the parasite, and the deviation to Th2 immune response including the production of anti-inflammatory cytokines, such as IL-10 may promote the parasite's survival causing the tissue immune destruction. Expand
Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones
TLDR
Helenalin acetate could be a useful anti-leishmanial scaffold for further optimization studies and is likely to potentiate the activity against the intracellular amastigotes. Expand
Immunization with excreted/secreted proteins in AS/n mice activating cellular and humoral response against Toxoplasma gondii infection.
TLDR
The protective immune response in the chronic infection was efficient in protecting the host against infection caused by other T. gondii strains, and can elicit high IgG1, IFN-γ and TNF-α production and, a lower amount of IgM, IgG2, IL-10 and IL-4, suggesting a mixed Th1/Th2 profile. Expand
Antitrypanosomal activity and evaluation of the mechanism of action of diterpenes from aerial parts of Baccharis retusa (Asteraceae).
TLDR
These data demonstrate, for the first time, the antitrypanosomal activity and mechanism of action of 1 and related compounds 2 and 3, obtained from aerial parts of B. retusa. Expand
Evolution of cytokine profile during the treatment of cerebral toxoplasmosis in HIV-infected patients.
TLDR
The evolution of the infection was correlated to restoration of IFN-γ response and a decrease of the inflammation and the evaluation of the immune response can provide valuable information and better monitoring of patients during specific treatment. Expand
Immunodiagnosis in cerebrospinal fluid of cerebral toxoplasmosis and HIV-infected patients using Toxoplasma gondii excreted/secreted antigens.
TLDR
ESA-ELISA and/or immunoblotting of CSF samples can be used for diagnosis of cerebral toxoplasmosis in association with clinical, serologic, and radiological information, thus providing a simple straightforward methodology, particularly suitable in countries with high prevalence of latent toxoplasmaosis in the general population. Expand
Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole
TLDR
The lethal action of econazole involved strong permeabilization of plasma membrane of promastigotes, with an overloaded ROS content that contributed to the death of parasites, and for the first time in literature, econAZole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites are reported. Expand
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