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A Landscape of Pharmacogenomic Interactions in Cancer
Summary Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies inExpand
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Evaluation of methods for modeling transcription factor sequence specificity
Genomic analyses often involve scanning for potential transcription factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed toExpand
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GW150914: First results from the search for binary black hole coalescence with Advanced LIGO.
On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-wave Observatory (LIGO) simultaneously observed the binary black hole merger GW150914. We report theExpand
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CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms
BackgroundCells process signals using complex and dynamic networks. Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiologicalExpand
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An upper limit on the stochastic gravitational-wave background of cosmological origin
A stochastic background of gravitational waves is expected to arise from a superposition of a large number of unresolved gravitational-wave sources of astrophysical and cosmological origin. It shouldExpand
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MEIGO: an open-source software suite based on metaheuristics for global optimization in systems biology and bioinformatics
BackgroundOptimization is the key to solving many problems in computational biology. Global optimization methods, which provide a robust methodology, and metaheuristics in particular have proven toExpand
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Searches for periodic gravitational waves from unknown isolated sources and Scorpius X-1: Results from the second LIGO science run
We carry out two searches for periodic gravitational waves using the most sensitive few hours of data from the second LIGO science run. Both searches exploit fully coherent matched filtering andExpand
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Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.
Genomic features are used as biomarkers of sensitivity to kinase inhibitors used widely to treat human cancer, but effective patient stratification based on these principles remains limited inExpand
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A template bank to search for gravitational waves from inspiralling compact binaries: I. Physical models
Gravitational waves from coalescing compact binaries are searched for using the matched filtering technique. As the model waveform depends on a number of parameters, it is necessary to filter theExpand
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Search for gravitational-wave bursts associated with gamma-ray bursts using data from LIGO Science Run 5 and Virgo Science Run 1
We present the results of a search for gravitational-wave bursts associated with 137 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments during the fifth LIGO scienceExpand
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