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Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of their… Expand
Synthesis and antituberculosis activity of new fatty acid amides.
- C. R. M. D'Oca, T. Coelho, +4 authors M. D'oca
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 September 2010
This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the… Expand
Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents.
- Fernanda Sifuentes Pinheiro Leitão, Suzana Guimarães Leitão, Mara Zélia de Almeida, Jéssica Cantos, Tatiane Silveira Coelho, Pedro Eduardo Almeida da Silva
- Medicine, Biology
- Journal of ethnopharmacology
- 16 September 2013
ETHNOPHARMACOLOGICAL RELEVANCE Several medicinal plants are traditionally traded in open-air markets in Rio de Janeiro State (Brazil) to treat tuberculosis (TB) and related symptoms. AIMS OF THE… Expand
Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles.
- P. E. Almeida da Silva, D. Ramos, +7 authors Marcos A P Martins
- Chemistry, Medicine
- International journal of antimicrobial agents
- 1 August 2008
A series of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-1H-1-isonicotinoyl-4,5-dihydropyrazoles (2a-i) were synthesised by the cyclocondensation reaction of… Expand
Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis
Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic resistance and also that the activity of the antibiotics subject to efflux can be enhanced by the combined… Expand
1,3-Azoles from ortho-naphthoquinones: synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis.
- K. C. G. Moura, P. F. Carneiro, +9 authors E. N. da Silva
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 November 2012
Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the… Expand
Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity
The municipality of Oriximina, Brazil, has 33 quilombola communities in remote areas, endowed with wide experience in the use of medicinal plants. An ethnobotanical survey was carried out in five of… Expand
The activity of flavones and oleanolic acid from Lippia lacunosa against susceptible and resistant Mycobacterium tuberculosis strains
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is the world's number one killer among infectious diseases. The search for new naturalproducts that can act as drugs against TB has received… Expand
Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.
- P. F. Carneiro, M. C. Pinto, +10 authors E. N. da Silva Júnior
- Medicine, Chemistry
- European journal of medicinal chemistry
- 1 September 2011
Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.… Expand
In vitro anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains
- T. Coelho, Jéssica Cantos, +4 authors M. V. N. Souza
- Infectious disease reports
- 2 January 2012
A series of twenty-three N-acylhydrazones derived from isoniazid (INH 1-23) have been evaluated for their in vitro antibacterial activity against INH- susceptible strain of M. tuberculosis (RG500)… Expand