• Publications
  • Influence
Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys.
The isoflavones in soy protein improve cardiovascular disease risk factors without apparent deleterious effects on the reproductive system of peripubertal rhesus monkeys. Expand
Understanding the divergent data on postmenopausal hormone therapy.
In contrast to observational studies, randomized clinical trials of hormone-replacement therapy have not shown a cardioprotective effect. The authors propose several methodologic and biologicExpand
Soy, soy phytoestrogens and cardiovascular disease.
  • T. Clarkson
  • Medicine
  • The Journal of nutrition
  • 1 March 2002
No definite experimental evidence exists currently to establish that the cardiovascular benefits of soy protein are accounted for by its isoflavones, but the best-documented effect is on plasma lipid and lipid concentrations. Expand
Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women.
There were significant interspecies differences in isoflavone metabolism, and the overall metabolic profile of pigs was closer to that of women than that of rats or monkeys. Expand
Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens.
Premenopausal cynomolgus monkeys were fed a moderately atherogenic diet to induce atherosclerosis, and both CEE and SPE significantly reduced the extent of common carotid and internalCarotid artery atheros sclerosis, and the two treatment groups were not significantly different. Expand
Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation
Observations support the view that the current obesity epidemic is the result of a primate adaptation involving the coevolution with encephalization of elaborate physiological systems to protect against starvation and defend stored body fat in order to feed a large and metabolically demanding brain. Expand
Estrogen replacement therapy, atherosclerosis, and vascular function.
Current evidence from studies of both monkeys and women suggest little or no attenuation of estrogen benefits for coronary artery atherosclerosis, which is a major problem in postmenopausal women. Expand
Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.
It is concluded that physiologic estrogen replacement Therapy with or without added progesterone inhibits atherosclerosis progression in ovariectomized monkeys, which may explain why estrogen replacement therapy results in reduced risk of coronary heart disease in postmenopausal women. Expand
Social Status, Environment, and Atherosclerosisin Cynomolgus Monkeys
The results suggest that social dominance (an Individual behavioral characteristic) Is associated with increased coronary artery atherosclerosis, but only under social conditions that provide recurrent threats to the status of dominant animals (I.e., under behavioral challenge). Expand
Evidence for up-regulation of brain-derived neurotrophic factor mRNA by soy phytoestrogens in the frontal cortex of retired breeder female rats
Both estradiol and soy phytoestrogens significantly increased the mRNA levels of BDNF compared to ovariectomized controls, suggesting that soy phytochemical agonists may act as estrogen agonists in regulating BDNF mRNA in the frontal cortex of retired breeder female rats. Expand