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  • Thomas O’Hare, William C. Shakespeare, +25 authors Tim Clackson
  • Medicine, Biology
  • Cancer cell
  • 2009 (First Publication: 3 November 2009)
  • Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain mutations can lead to relapse and aExpand
  • Sen Zhang, Rana Anjum, +24 authors Victor M. Rivera
  • Medicine, Biology
  • Clinical Cancer Research
  • 2016 (First Publication: 25 October 2016)
  • Purpose: Non–small cell lung cancers (NSCLCs) harboring ALK gene rearrangements (ALK+) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitorExpand