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Antioxidants as novel therapy in a murine model of colitis.
- H. Oz, T. Chen, C. McClain, W. D. de Villiers
- The Journal of nutritional biochemistry
- 1 May 2005
Reactive oxygen species (ROS) are increased in inflammatory bowel disease (IBD) and have been implicated as mediators of intestinal inflammation. We investigated the hypothesis that antioxidants with… Expand
The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids.
It is unknown how the interdigestive migrating motor complex influences the gastric emptying of liquids. Therefore, the gastric emptying rate of 50- and 200-mL volumes of phenol red solution were… Expand
Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats.
The Smith-Lemli-Opitz syndrome is a recessive inherited disorder characterized by neurologic developmental defects and dysmorphic features in many organs. Recently, abnormal cholesterol biosynthesis… Expand
Glutathione‐enhancing agents protect against steatohepatitis in a dietary model
- H. Oz, Hee-jeong Im, T. Chen, W. D. de Villiers, C. McClain
- Journal of biochemical and molecular toxicology
- 1 February 2006
Nonalcoholic fatty liver (NAFL) and steatohepatitis (NASH) may accompany obesity, diabetes, parenteral nutrition, jejeuno‐ileal bypass, and chronic inflammatory bowel disease. Currently there is no… Expand
Adaptations of Ligamentum Teres in Ischemic Necrosis of Human Femoral Head
- H. Chen, A. Li, K. C. Li, J. Wu, T. Chen, M. Lee
- Clinical orthopaedics and related research
- 1 July 1996
Little is known about the biomechanical properties of human ligamentum teres. To more fully understand the ligamentum teres, its dimensions and mechanical properties were measured in 22 cases of… Expand
Efficacy of a Transforming Growth Factor β2 Containing Nutritional Support Formula in a Murine Model of Inflammatory Bowel Disease
Objective: Dietary, environmental and genetic events may influence host susceptibility to inflammatory bowel diseases (IBD). Transforming growth factor β2 (TGF-β2), a multifunctional polypeptide… Expand
Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice.
- G. Arteel, L. Guo, +8 authors J. C. States
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 15 January 2008
Exposure to arsenic via drinking water is a serious health concern in the US. Whereas studies have identified arsenic alone as an independent risk factor for liver disease, concentrations of arsenic… Expand
Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats
1 The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2 Gastric emptying was inhibited both acutely and chronically by… Expand
Life span profiles of glutathione and acetaminophen detoxification.
- T. Chen, J. Richie, C. Lang
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 November 1990
Our previous finding of a glutathione (GSH) deficiency in aging or senescent mice suggested that a concomitant decrease in detoxification capacity also may occur. To test this, mice at different… Expand
Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model.
Oxidant-mediated injury plays an important role in the pathophysiology of inflammatory bowel disease (IBD). Recently, antioxidants were shown to modulate colitis in mice. In this study, the… Expand