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Implantation of a Miniature Glaucoma Device Under a Scleral Flap
TLDR
The Ex-PRESS™ device was found to be safe and effective with few complications when it is implanted under a scleral flap even in the high-risk patients studied. Expand
A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases.
TLDR
This review focuses on various aspects of intravitreal drug delivery such as the impediment of the blood-ocular barriers, the potential sites or intraocular drug delivery device implantation, the various approaches employed for ophthalmic drug delivery and includes a concise critical incursion into specialized intrav itreal implantable technologies for the treatment of anterior and posterior segment eye disease. Expand
Corneal ulceration at an urban African hospital.
TLDR
During a one-year survey 283 corneal ulcers from 274 patients were seen at St John's Eye Unit of Baragwanath Hospital, many of the patients were male Africans who were either manual labourers or unemployed. Expand
Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.
TLDR
Findings support a functional role for the LOXL1-AS1 lncRNA in cellular stress response and suggest that dysregulation of its expression by genetic risk variants plays a key role in XFS pathogenesis. Expand
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
TLDR
A genome-wide significant association between a new locus (CACNA1A rs4926244) and increased susceptibility to XFS is discovered and represents the first genetic locus outside of LOXL1 surpassing genome- wide significance for XFS and provides insight into the biology and pathogenesis of the disease. Expand
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population
TLDR
Surprisingly, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of XFG and is found with a strong association with the opposite allele in the South African population. Expand
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci
TLDR
A rare protective allele at LOXL1 is identified through deep resequencing of XFS cases and controls and a potential role for naturally occurring rare LO XL1 variants in disease biology is highlighted. Expand
Myocilin mutations in black South Africans with POAG
TLDR
A small minority of black South Africans with POAG carry MYOC mutations, and the Tyr453MetFSX11 mutation appears to be a glaucoma-causing mutation with incomplete penetrance. Expand
The Genetics of POAG in Black South Africans: A Candidate Gene Association Study
TLDR
This first POAG genetic association study in black South Africans has identified associations that require additional investigation in this and other populations to determine their significance and highlights the need for larger studies in this population if the goal of facilitating early POAG detection and ultimately preventing irreversible blindness from this condition is achieved. Expand
A review of topically administered mini‐tablets for drug delivery to the anterior segment of the eye
TLDR
The human eye is a unique and intricate structure which has made drug delivery to the eye a formidable undertaking, and the development of novel drug delivery systems for improved treatment is imperative. Expand
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