T. Carew

Publications224
h-index57
Citations10,673
Highly Influential Citations423
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A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
TLDR
Results of these cellular experiments are quantitatively similar to the results of behavioral experiments with the same protocol and parameters, suggesting that activity-dependent amplification of presynaptic facilitation may make a significant contribution to classical conditioning of the withdrawal reflex.
Multiple overlapping processes underlying short-term synaptic enhancement
TLDR
Results suggest that these processes can now be distinguished mechanistically by the site of their induction within the presynaptic terminal: FI and F2 appear to be induced by a rapid, high concentration of Ca2+ at or near the sites of exocytosis, whereas AUG and PTP seem to beinduced by lower levels of Ca 2+ with slower kinetics, possibly within the core of the terminal.
Ontogeny of serotonergic neurons in Aplysia californica
  • R. Marois, T. Carew
  • Biology, Medicine
    The Journal of comparative neurology
  • 29 September 1997
TLDR
The view that the larval and adult forms of the Aplysia nervous system consist of entirely distinct sets of serotonergic cells, each adapted to the stage‐specific morphological and behavioral characteristics of the animal is supported.
Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons.
TLDR
Short-term and long-term synaptic facilitation are induced in parallel in the sensory neurons and that the short-term process, because it is induced and expressed at the synapse, can occur locally, but the long- term process,Because of its dependence on a nuclear signal, is expressed throughout the neuron.
Differential induction of long-term synaptic facilitation by spaced and massed applications of serotonin at sensory neuron synapses of Aplysia californica.
TLDR
Whereas induction of ITF and LTF require similar amounts of 5HT, the cellular mechanisms underlying the induction of LTF are more sensitive to the pattern of the induction trials, suggesting that these two processes may be mechanistically related.
Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia
TLDR
It is demonstrated that SN-MN synapses can exhibit two distinct forms of ITF that are mediated by parallel molecular pathways that require persistent activation of PKC but not PKA.
Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C
TLDR
It is shown that a single tail shock can also induce ITM that is expressed selectively at the trained site (site-specific ITM), which is phenotypically similar to the form of ITM induced by repeated trials, but the mechanisms by which site- specific ITM is induced and maintained are distinct.
Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia
TLDR
It is shown that tyrosine kinases play a direct role in long-term synaptic facilitation (LTF) and long- term memory (LTM) for sensitization in Aplysia and activation of endogenous tyrosin kinases enhances the induction ofLong-term memory for sensitizing, and this enhancement requires MAPK activation.
Mechanoafferent neurons innervating tail of Aplysia. I. Response properties and synaptic connections.
TLDR
The mechanoafferent neurons innervating the tail region make strong monosynaptic connections to tail motor neurons in the ipsilateral pedal ganglion, and through these connections this subpopulation of the VC neurons appears to make a substantial contribution to the short-latency tail-withdrawal reflex.
Classical conditioning in a simple withdrawal reflex in Aplysia californica
The ability of Aplysia and other gastropod molluscs to exhibit complex behaviors that can be modified by associative learning has encouraged us to search for an elementary behavior controlled by a…
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