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- Publications
- Influence
A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
- R. Hawkins, T. Abrams, T. Carew, E. Kandel
- Chemistry, Medicine
- Science
- 28 January 1983
A training procedure analogous to differential classical conditioning produces differential facilitation of excitatory postsynaptic potentials (EPSP's) in the neuronal circuit for the siphon… Expand
Multiple overlapping processes underlying short-term synaptic enhancement
- Stephen A. Fisher, T. Fischer, T. Carew
- Chemistry, Medicine
- Trends in Neurosciences
- 1 May 1997
Recently there have been exciting advances in understanding the mechanisms and functional roles of a form of short-term synaptic enhancement (STE) that results from an activity-dependent accumulation… Expand
Ontogeny of serotonergic neurons in Aplysia californica
Although the identity, projection patterns, and functions of serotonergic neurons in juvenile and adult Aplysiaare relatively well understood, little is known about the development of these cells. We… Expand
Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C
- M. A. Sutton, M. Bagnall, S. K. Sharma, J. Shobe, T. Carew
- Biology, Medicine
- The Journal of Neuroscience
- 7 April 2004
Recent studies of long-term synaptic plasticity and long-term memory have demonstrated that the same functional endpoint, such as long-term potentiation, can be induced through distinct signaling… Expand
Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons.
- N. Emptage, T. Carew
- Biology, Medicine
- Science
- 8 October 1993
Serotonin (5-HT) induces both short-term and long-term facilitation of the identified synaptic connections between sensory and motor neurons of Aplysia. Three independent experimental approaches… Expand
Differential induction of long-term synaptic facilitation by spaced and massed applications of serotonin at sensory neuron synapses of Aplysia californica.
- J. Mauelshagen, C. M. Sherff, T. Carew
- Psychology, Medicine
- Learning & memory
- 1 July 1998
Serotonin (5HT)-induced facilitation of synaptic transmission from tail sensory neurons (SNs) to motor neurons (MNs) in the marine mollusc Aplysia provides a cellular model of short- and long-term… Expand
Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia
- M. A. Sutton, T. Carew
- Biology, Medicine
- Neuron
- 1 April 2000
Three distinct temporal phases of synaptic facilitation (short-, intermediate-, and long-term) are induced by serotonin (5-HT) at sensory (SN) to motor (MN) synapses in Aplysia. Here, we characterize… Expand
Mechanoafferent neurons innervating tail of Aplysia. I. Response properties and synaptic connections.
- E. Walters, J. Byrne, T. Carew, E. Kandel
- Chemistry, Medicine
- Journal of neurophysiology
- 1 December 1983
Mechanical, chemical, or electrical stimulation of the tail elicits a short-latency (less than 1 s) tail-withdrawal reflex that is graded with the intensity of the stimulus. The tail-withdrawal… Expand
Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia
- A. L. Purcell, S. K. Sharma, M. Bagnall, M. A. Sutton, T. Carew
- Biology, Medicine
- Neuron
- 6 February 2003
Tyrosine kinases have been implicated in cellular processes thought to underlie learning and memory. Here we show that tyrosine kinases play a direct role in long-term synaptic facilitation (LTF) and… Expand
Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in Aplysia
- S. K. Sharma, C. M. Sherff, J. Shobe, M. Bagnall, M. A. Sutton, T. Carew
- Biology, Medicine
- The Journal of Neuroscience
- 1 May 2003
The mitogen-activated protein kinase (MAPK) pathway has been implicated recently in synaptic plasticity and memory. Here we used tail shock-induced sensitization of the tail-elicited siphon… Expand