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Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but stimulates… Expand
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
- R. Saxena, C. Elbers, +152 authors B. Keating
- Biology, Medicine
- American journal of human genetics
- 9 March 2012
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000… Expand
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With…
Background— Adeno-associated virus type 1/sarcoplasmic reticulum Ca2+-ATPase was assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with advanced heart failure.… Expand
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide… Expand
BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
Heart failure (HF) is driven by the interplay between regulatory transcription factors and dynamic alterations in chromatin structure. Pathologic gene transactivation in HF is associated with… Expand
The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease.
OBJECTIVES This study sought to evaluate if diastolic pulmonary gradient (DPG) can predict survival in patients with pulmonary hypertension due to left heart disease (PH-LHD). BACKGROUND Patients… Expand
Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure.
- J. Testani, T. Cappola, C. Brensinger, R. Shannon, S. Kimmel
- Journal of the American College of Cardiology
- 19 July 2011
OBJECTIVES The purpose of this study was to investigate whether a surrogate for renal neurohormonal activation, blood urea nitrogen (BUN), could identify patients destined to experience adverse… Expand
Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction
Background— Inorganic nitrate (NO3−), abundant in certain vegetables, is converted to nitrite by bacteria in the oral cavity. Nitrite can be converted to nitric oxide in the setting of hypoxia. We… Expand
High-Sensitivity ST2 for Prediction of Adverse Outcomes in Chronic Heart Failure
Background—Soluble ST2 reflects activity of an interleukin-33–dependent cardioprotective signaling axis and is a diagnostic and prognostic marker in acute heart failure. The use of ST2 in chronic… Expand
Transcriptional Genomics Associates FOX Transcription Factors With Human Heart Failure
Background— Specific transcription factors (TFs) modulate cardiac gene expression in murine models of heart failure, but their relevance in human subjects remains untested. We developed and applied a… Expand