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Long story short: the serotonin transporter in emotion regulation and social cognition
The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that has been associated with anxiety-related traits and susceptibility for depression. Here we highlight recent
Amygdala Responses to Emotionally Valenced Stimuli in Older and Younger Adults
Both older and younger adults showed greater activation in the amygdala for emotional than for neutral pictures; however, for older adults, seeing positive pictures led to greater amygdala activation than seeing negative pictures, whereas this was not the case for younger adults.
An fMRI study of personality influences on brain reactivity to emotional stimuli.
This study provides direct evidence that personality is associated with brain reactivity to emotional stimuli and identifies both common and distinct brain regions where such modulation takes place.
Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat.
Analysis of behavioral and neural correlates of emotional reactivity and cognitive regulation in patients and controls during processing of social and physical threat stimuli helps to elucidate potential neural mechanisms of emotion regulation that might serve as biomarkers for interventions for social anxiety disorder.
Functional brain mapping of extraversion and neuroticism: learning from individual differences in emotion processing.
  • T. Canli
  • Psychology, Biology
    Journal of personality
  • 1 December 2004
How functional brain imaging, using an individual-differences approach in the processing of emotional stimuli, has begun to reveal the neural basis of extraversion and neuroticism, two traits that are linked to both emotion and health are outlined.
Neural correlates of epigenesis
  • T. Canli, M. Qiu, K. Lesch
  • Psychology, Biology
    Proceedings of the National Academy of Sciences
  • 24 October 2006
Support is found for a model by which life stress interacts with the effect of serotonin transporter genotype on amygdala and hippocampal resting activation, two regions involved in depression and stress, which may constitute a neural mechanism for epigenetic vulnerability toward, or protection against, depression.
Amygdala Response to Happy Faces as a Function of Extraversion
Cognitive neuroscience aims to delineate principles of brain-behavior relations by characterizing both common mechanisms across, and individual differences among, individuals. Both approaches are
Sex differences in the neural basis of emotional memories
Women had significantly more brain regions where activation correlated with both ongoing evaluation of emotional experience and with subsequent memory for the most emotionally arousing pictures, and greater overlap in brain regions sensitive to current emotion and contributing to subsequent memory may be a neural mechanism for emotions to enhance memory more powerfully in women than in men.
Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task.
Functional and structural differences suggest a much broader role for 5-HT transport efficiency in brain processes than previously thought, particularly in frontal cortical regions, anterior cingulate, and cerebellum.
Event-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience
The view that amygdala activation reflects moment-to-moment subjective emotional experience and that this activation enhances memory in relation to the emotional intensity of an experience is supported.