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BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology
TLDR
Preclinical data suggest that BF2.649 is a valuable drug candidate to be developed in wakefulness or memory deficits and other cognitive disorders.
Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance
TLDR
A phleomycin-resistance gene (Sh ble) is cloned from the genomic DNA of Streptoalloteichus hindustanus (ATCC 31158) and its polylinker and tallysomycins which are active at low concentrations on both fragments.
uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.
TLDR
It is shown here that DENN domains are much larger than described to date in domain databases, always encircled on both sides by more divergent domains, that are called uDENN and dDENN, which share conserved amino acids which could play a key role in the DENN functions.
Cell Type-specific Localization of Human Cardiac S1P Receptors
TLDR
The present results provide new insight into the expression pattern of S1P receptor in human cardiovascular tissues, indicating a differential pattern of expression for these receptors in human vessels.
Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.
TLDR
Results show that p63RhoGEF is a RhoA-specific GEF that may play a key role in actin cytoskeleton reorganization in different tissues, especially in heart cellular morphology.
Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells.
TLDR
It is demonstrated that increased BLM hydrolase activity in NIH 3T3 cells causes BLM resistance and that inhibition of BLM metabolism sensitizes these cells to BLM.
Cloning, expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus.
TLDR
The nucleotide sequence of a 2052 bp DNA fragment containing the TcR structural gene from S. rimosus has been determined and shows a limited but significant homology to other characterized tetracycline transport acting determinants from pathogenic bacteria.
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