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Responsiveness to 6-n-Propylthiouracil (PROP) Is Associated with Salivary Levels of Two Specific Basic Proline-Rich Proteins in Humans
The findings suggest that PRB1, in addition to TAS2R38 and gustin, could contribute to individual differences in thiourea sensitivity, and the expression of the PROP phenotype as a complex genetic trait. Expand
Facts and artifacts in proteomics of body fluids. What proteomics of saliva is telling us?
Several technological and analytical problems and pitfalls that had to be surmounted during studies focussed on the extensive qualitative and quantitative characterization of salivary peptidoma and mainly based on LC-MS analyses of intact naturally occurring peptides are described. Expand
Trafficking and Postsecretory Events Responsible for the Formation of Secreted Human Salivary Peptides
To elucidate the localization of post-translational modifications of different classes of human salivary proteins and peptides (acidic and basic proline-rich proteins (PRPs), Histatins, Statherin,Expand
Characterization of the human salivary basic proline-rich protein complex by a proteomic approach.
A correlation matrix analysis revealed a cluster of correlation among all the basic PRPs (apart from the P-B peptide) which is in agreement with their common parotid origin. Expand
Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes
The study revealed that statherin, proline-rich peptide P-B, P-C peptide, and histatins, were significantly less concentrated in saliva of diabetic subjects than in controls, while concentration of α-defensins 1, 2 and 4 and S100A9* was higher. Expand
Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS.
The acidic-soluble protein content of human gingival crevicular fluid was analyzed by reverse-phase high-performance liquid chromatography (RP-HPLC), and the eluent deriving from the chromatographyExpand
Proteomic study of salivary peptides and proteins in patients with Sjögren's syndrome before and after pilocarpine treatment.
Pilocarpine partially restored the levels and numbers of identifiable proteins in saliva from patients with primary Sjögren's syndrome and could be markers of oral inflammation in this patient group. Expand
Potential applications of human saliva as diagnostic fluid
The characterization by proteomic approaches of new salivary markers in oncology, head and neck carcinoma, breast and gastric cancers, salvary gland function and disease, Sjögren syndrome, systemic sclerosis, dental and gingival pathology, systemic, psychiatric and neurological diseases, is described. Expand
Different isoforms and post‐translational modifications of human salivary acidic proline‐rich proteins
The human salivary acidic proline‐rich proteins (aPRPs) complex was investigated by different chromatographic and mass spectrometric approaches and the main aPRPs, namely PRP‐1,PRP‐2 and PIF‐s, Db‐s and Pa, and several previously undetected aPRP derivatives were found. Expand
Identification of the human salivary cystatin complex by the coupling of high‐performance liquid chromatography and ion‐trap mass spectrometry
High‐performance liquid chromatography electrospray ionization mass spectrometry (HPLC‐ESI MS) was applied to the analysis of human saliva obtained from healthy subjects and all known salivary cystatins, with the exception of cystatin C, were detected. Expand