T. C. Moon
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Advances in mast cell biology: new understanding of heterogeneity and function
Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases. However, over the last decade our understanding has been enriched about their roles in host defense, innate and… Expand
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells.
- Seok-Jong Suh, Tae-Wook Chung, +6 authors Cheorl-ho Kim
- Biology, Medicine
- Archives of biochemistry and biophysics
- 15 March 2006
Ochnaflavone (OC), a naturally occurring biflavonoid with anti-inflammatory activity [S.J. Lee, J.H. Choi, H.W. Chang, S.S. Kang, H.P. Kim. Life Sci. 57(6), 1995, 551-558], was isolated from Lonicera… Expand
Expression of DP2 (CRTh2), a Prostaglandin D2 Receptor, in Human Mast Cells
PGD2 has long been implicated in allergic diseases. Recent cloning of a second PGD2 receptor, DP2 (also known as CRTh2), led to a greater understanding of the physiological and pathophysiological… Expand
Mast Cell Mediators: Their Differential Release and the Secretory Pathways Involved
Mast cells (MC) are widely distributed throughout the body and are common at mucosal surfaces, a major host–environment interface. MC are functionally and phenotypically heterogeneous depending on… Expand
Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2′,4,4′,5,5′-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation
Mast cells are critical for initiating innate immune and inflammatory responses by releasing a number of pro-inflammatory mediators. The potential immunomodulatory properties of hydrogenated aromatic… Expand
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
- Seung-Lark Hwang, Y. Lu, +10 authors H. Chang
- Chemistry, Biology
- The Journal of allergy and clinical immunology
- 28 August 2014
BACKGROUND Extracellular signal-regulated kinases 1/2 (ERK1/2) make important contributions to allergic responses via their regulation of degranulation, eicosanoid production, and cytokine expression… Expand
Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity
- Ming Shan Zheng, Nam Kyung Hwang, D. H. Kim, T. C. Moon, J. Son, H. Chang
- Medicine, Chemistry
- Archives of pharmacal research
- 13 April 2008
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum… Expand
Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells.
- T. C. Moon, M. Murakami, M. Ashraf, I. Kudo, H. W. Chang
- Biology, Medicine
- Cellular immunology
- 1 May 1998
Emerging evidence has suggested the pivotal role of mast cells in a host defense against bacterial infection. In this paper, we report that bacterial lipopolysaccharide (LPS) is a potent enhancer of… Expand
Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells.
- Y. Taketomi, Toshihiko Sugiki, +11 authors I. Kudo
- Medicine, Biology
- Biochemical and biophysical research…
- 27 June 2003
Coculture of mouse bone marrow-derived mast cells (BMMC) with fibroblasts in the presence of stem cell factor (SCF) facilitates morphological and functional maturation toward a connective tissue mast… Expand
Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
- J. Son, Min Jung Son, +6 authors H. Chang
- Medicine, Chemistry
- Biological & pharmaceutical bulletin
- 1 December 2005
Ginkgetin, a biflavone from Ginkgo biloba leaves, was previously reported to be a phospholipase A(2) inhibitor and this compound showed the potent antiarthritic activity in rat adjuvant-induced… Expand