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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Marine-derived fungi: a chemically and biologically diverse group of microorganisms.
A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally,…
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
It is proposed that WLS binds Wnts in part through a lipid-binding domain, and that vacuolar acidification is required to release palmitoylated WNT3A from WLS in secretory vesicles, possibly to facilitate transfer of Wnt3A to a soluble carrier protein.
Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
- S. Pimentel-Elardo, Svitlana Kozytska, T. Bugni, C. Ireland, H. Moll, U. Hentschel
- Biology, ChemistryMarine drugs
- 23 February 2010
Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we…
Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.
- T. Wyche, Yanpeng Hou, E. Vazquez-Rivera, Doug R. Braun, T. Bugni
- Biology, ChemistryJournal of natural products
- 27 April 2012
A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously…
The antimicrobial potential of Streptomyces from insect microbiomes
The antimicrobial potential of insect-associated Streptomyces is uncovered and a compound, cyphomycin, active against multidrug-resistant fungal pathogens is identified, indicating host microbiomes are feasible sources for drug discovery.
Species specificity of symbiosis and secondary metabolism in ascidians
The analysis here streamlines the connection of secondary metabolite to producing bacterium, enabling further biological and biotechnological studies, and reveals fundamental properties of secondary metabolic symbiosis.
Genome-Based Cluster Deletion Reveals an Endocrocin Biosynthetic Pathway in Aspergillus fumigatus
This work describes the biosynthetic and regulatory characterization of the endocrocin gene cluster in Aspergillus fumigatus and discusses a model of the enc cluster as one evolutionary origin of fungal anthraquinones derived from a nonreducing polyketide synthase and a discrete metallo-β-lactamase-type thioesterase.
Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach
- Navid Adnani, E. Vazquez-Rivera, Srikar N. Adibhatla, Gregory A Ellis, Doug R. Braun, T. Bugni
- BiologyMarine drugs
- 24 September 2015
The results suggest that interspecies interactions were prevalent between marine Micromonosporaceae and marine mycolic acid-containing bacteria, and highlights a sensitive and rapid method for investigating inter species interactions in search of novel antibiotics, secondary metabolites, and genes.
Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.
Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete,…