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Dual-specificity phosphatases: critical regulators with diverse cellular targets.
DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the oneExpand
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Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. AExpand
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Function, regulation and pathological roles of the Gab/DOS docking proteins
Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS family have emerged as important signalling elements in metazoans. Gab/DOS proteins integrate and amplifyExpand
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Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
Activation of the MAPK signaling pathway has been shown to be a unifying molecular feature in pilocytic astrocytoma (PA). Genetically, tandem duplications at chromosome 7q34 resulting inExpand
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Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneityExpand
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  • Open Access
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
The extracellular signal-regulated kinase (ERK) pathway plays an important role during the development and activation of B lymphocytes. We have recently shown that B-Raf is a dominant ERK activatorExpand
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Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma
Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated Ras/Raf/MEK/ERK signaling. Common genetic lesions observed in PA, which are linked to aberrant ERK pathway activity, includeExpand
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Feedback regulation of lymphocyte signalling
The development, survival and activation of lymphocytes is controlled by a multitude of extracellular signals in the form of soluble or membrane-bound ligands. Binding of these ligands to receptorsExpand
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  • Open Access
ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy.
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Increased Proliferation and Altered Growth Factor Dependence of Human Mammary Epithelial Cells Overexpressing the Gab2 Docking Protein*
The docking protein Gab2 is a proto-oncogene product that is overexpressed in primary breast cancers. To determine the functional consequences of Gab2 overexpression, we utilized the immortalizedExpand
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