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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
- T. Breitman, S. Selonick, S. Collins
- BiologyProceedings of the National Academy of Sciences…
- 1 May 1980
This study suggests that retinoids could provide a therapeutic tool in the treatment of acute myeloid leukemia, and indicates thatretinoids, in addition to their well-characterized involvement in epithelial cell differentiation, may also be involved in the differentiation of certain hematopoietic cells.
Terminal Differentiation of Human Promyelocytic Leukemic Cells in Primary Culture in Response to Retinoic Acid
Because it appears that retinoic acid specifically induces granulocytic differentiation of leukemic promyelocytes, this compound may have therapeutic utility in the treatment of acute Promyelocytic leukemia.
The feedback inhibition of thymidine kinase.
- T. Breitman
- BiologyBiochimica et biophysica acta
Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy.
The results suggest that the readily available TB may be an effective prodrug of BA and may be useful either as a sole agent or in combination with other agents for cytodifferentiation therapy of human malignancies.
Replacement of serum by insulin and transferrin supports growth and differentiation of the human promyelocytic cell line, HL-60.
Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin.
The human monocytic leukemia cell line, THP-1, is induced to differentiate into more functionally mature monocyte (macrophage)-like cells by incubation with retinoic acid at concentrations of 10nM or…
Inability of low thymine-requiring mutants of Escherichia coli lacking phosphodeoxyribomutase to be induced for deoxythymidine phosphorylase and deoxyriboaldolase
Metabolism of deoxythymidine (dThd) by growing cultures of Escherichia colia suggested that deoxyribose 5-phosphate (dR-5-P) was moredirectly involved with inductions than was deoxy ribose 1-ph phosphate ( dR-1-P), the compound implicated by W.E.Razzell and P.Casshyap.
Arabinofuranosyl-5-azacytosine: antitumor and cytotoxic properties.
Its broad spectrum antitumor activity, its selective toxicity to tumor cells, and its ability to produce cytodifferentiation render ara-AC of interest as a potential antineoplastic agent in humans.
Priming of human myeloid leukemic cell lines HL-60 and U-937 with retinoic acid for differentiation effects of cyclic adenosine 3':5'-monophosphate-inducing agents and a T-lymphocyte-derived…
The finding that myeloid cell lines, like HL-60 and U-937, blocked at a late stage of maturation can be primed by RA to respond to cAMP-inducing agents and differentiation-inducing factor may improve the understanding of the arrest in maturation typical of some forms of leukemia.
Structure-activity relationships of a new series of retinoidal benzoic acid derivatives as measured by induction of differentiation of murine F9 teratocarcinoma cells and human HL-60 promyelocytic…
- S. Strickland, T. Breitman, F. Frickel, A. Nürrenbach, E. Hädicke, M. Sporn
- Chemistry, BiologyCancer research
- 1 November 1983
These new retinoids should be useful agents for experimental studies of both cancer prevention and treatment, as well as for investigation of the mechanism of action of retinoid in the control of cell differentiation.