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Computer Simulation of Rockfalls
The Colorado Rockfall Simulation Program (CRSP) is a computer program written in BASIC which models rockfall behavior and provides a statistical analysis of rockfall simulations at a given site. ThisExpand
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Outcome of unrelated donor bone marrow transplantation in 40 children with Hurler syndrome.
Long-term survival and improved neuropsychological function have occurred in selected children with Hurler syndrome (MPS I H) after successful engraftment with genotypically matched sibling boneExpand
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Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.
We have previously demonstrated that transforming growth factor-beta1 (TGF-beta1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (HA) pericellularExpand
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Involvement of Hyaluronan in Regulation of Fibroblast Phenotype*
This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by assessing its impact on regulating fibroblast behavior. Donor-matchedExpand
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Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44
Background: Wound healing and scarring are driven by transforming growth factor-β1 (TGF-β1)-dependent fibroblast to myofibroblast differentiation. Results: Cell surface CD44 and epidermal growthExpand
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The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell♦
Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension, osteoarthritis, asthma, thyroid dysfunction,Expand
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miR-192 induces G2/M growth arrest in aristolochic acid nephropathy.
Aristolochic acid nephropathy is characterized by rapidly progressive tubulointerstitial nephritis culminating in end-stage renal failure and urothelial malignancy. Profibrotic effects ofExpand
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Acute kidney injury: a paradigm for miRNA regulation of the cell cycle.
miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) inExpand
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MicroRNAs, transforming growth factor beta‐1, and tissue fibrosis
MicroRNAs are short noncoding RNA regulators that repress synthesis of their targets post‐transcriptionally. On average, each microRNA is estimated to regulate several hundred protein‐coding genes,Expand
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Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation*
Background: Intracellular proteins glycosylation with O-GlcNAc is able to influence cell microenvironment. Results: O-GlcNAcylation increases hyaluronan synthase 2 (HAS2) transcription via itsExpand
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