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Zika virus in the Americas: Early epidemiological and genetic findings
Results of phylogenetic and molecular clock analyses show a single introduction of ZikV into the Americas, which is estimated to have occurred between May and December 2013, more than 12 months before the detection of ZIKV in Brazil.
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution, which may exhibit increased transmissibility and/or immune evasion, which is critical to accelerate pandemic responsiveness.
Toremifene interacts with and destabilizes the Ebola virus glycoprotein
The results suggest that inhibitor binding destabilizes GP and triggers premature release of GP2, thereby preventing fusion between the viral and endosome membranes, which reveals the mechanism of inhibition and may guide the development of more powerful anti-EBOV drugs.
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
Crystal structures of both Nipah and Hendra attachment glycoproteins in complex with human EFNB2 provide a structural template to target antiviral inhibition of protein-protein interactions.
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection
In infected mice, the envelope glycan shield promoted protracted viral infection by preventing its timely elimination by the ensuing antibody response, which imposes limitations on antibody-based vaccination and convalescent serum therapy.
Evidence for henipavirus spillover into human populations in Africa
To determine the potential for HNV spillover events among humans in Africa, well-curated sets of bat and human serum samples from Cameroon are examined for Nipah virus (NiV) cross-neutralizing antibodies ( NiV-X-Nabs).