• Publications
  • Influence
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
TLDR
How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.
Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies
TLDR
Interventions using current tools can result in major reductions in P. falciparum malaria transmission and the associated disease burden in Africa, although considerable reductions in prevalence can be achieved with existing tools and realistic coverage levels.
Factors determining the occurrence of submicroscopic malaria infections and their relevance for control
TLDR
It is shown that submicroscopic parasite carriage is common in adults, in low-endemic settings and in chronic infections, and challenge the idea that individuals with little previous malaria exposure have insufficient immunity to control parasitaemia and suggest a role for molecular screening.
Hitting Hotspots: Spatial Targeting of Malaria for Control and Elimination
TLDR
It is argued that targeting malaria “hotspots” is a highly efficient way to reduce malaria transmission at all levels of transmission intensity.
Asymptomatic malaria infections: detectability, transmissibility and public health relevance
TLDR
It is argued that wider deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts and the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission.
Targeting Asymptomatic Malaria Infections: Active Surveillance in Control and Elimination
TLDR
It is argued that the evidence for its effectiveness is sparse and that targeted mass drug administration should be evaluated as an alternative or addition to active case detection.
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
TLDR
The first transcriptome analysis of male and female Plasmodium falciparum gametocytes coupled with a comprehensive proteome analysis is reported, revealing 512 highly expressed maternal transcripts without corresponding protein expression indicating large scale translational repression in P. falcIParum female gametocyte for the first time.
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
TLDR
These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites.
Primaquine Clears Submicroscopic Plasmodium falciparum Gametocytes that Persist after Treatment with Sulphadoxine-Pyrimethamine and Artesunate
TLDR
For individuals without severe anaemia, addition of a single dose of PQ to an efficacious antimalarial drug combination is a safe approach to reduce malaria transmission following treatment.
Identification of hot spots of malaria transmission for targeted malaria control.
TLDR
Serological markers were able to detect spatial variation in malaria transmission at the microepidemiological level, and they have the potential to form an effective method for spatial targeting of malaria control efforts.
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