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Homocysteine and folate metabolism in depression
  • T. Bottiglieri
  • Medicine
    Progress in Neuro-Psychopharmacology and…
  • 1 September 2005
TLDR
The biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression are described.
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
TLDR
Abnormal lipid deposition in the proximal portion of the aorta was observed in older heterozygotes and homozygotes, alluding to an atherogenic effect of hyperhomocysteinemia in these mice.
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.
TLDR
Although the vitamin supplement regimen was effective in reducing homocysteine levels, it had no beneficial effect on the primary cognitive measure, rate of change in ADAS-cog score during 18 months, and this regimen of high-dose B vitamin supplements does not slow cognitive decline in individuals with mild to moderate AD.
Homocysteine, folate, methylation, and monoamine metabolism in depression
TLDR
A biological subgroup of depression with folate deficiency, impaired methylation, and monoamine neurotransmitter metabolism has been identified and Detection of this subgroup, which will not be achieved by routine blood counts, is important in view of the potential benefit of vitamin replacement.
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule.
  • T. Bottiglieri
  • Medicine
    The American journal of clinical nutrition
  • 1 November 2002
TLDR
An overview of the biochemical, molecular, and therapeutic effects of SAMe is provided, including those on depression, dementia, vacuolar myelopathy, liver disease, and osteoarthritis.
Folate, vitamin B12, and neuropsychiatric disorders.
TLDR
The neurotoxic effects of homocysteine may also play a role in the neurologic and psychiatric disturbances that are associated with folate and vitamin B12 deficiency.
Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy.
TLDR
Plasma beta-amyloid 40 concentration is independently associated with extent of white matter hyperintensity in subjects with Alzheimer disease, mild cognitive impairment, or cerebral amyloid angiopathy, and if confirmed in longitudinal studies, these data would suggest circulating beta-Amyloid peptide as a novel biomarker or risk factor for microvascular damage in these common diseases of the elderly.
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
TLDR
Folic acid and possibly other nontoxic dietary methyl donors may therefore be useful in clinical interventions to promote brain and spinal cord healing and provide possible avenues for new pharmacologic approaches to treating CNS injuries.
L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials.
TLDR
Adjunctive L-methylfolate at 15 mg/day may constitute an effective, safe, and relatively well tolerated treatment strategy for patients with major depressive disorder who have a partial response or no response to SSRIs.
Folate, vitamin B12, and homocysteine in major depressive disorder.
TLDR
Folate levels might be considered in the evaluation of depressed patients who do not respond to antidepressant treatment, consistent with findings linking low folate levels to poorer response to antidepressants.
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