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Direct adsorption of low‐density lipoprotein and lipoprotein(a) from whole blood: Results of the first clinical long‐term multicenter study using DALI apheresis
Direct adsorption of lipoproteins (DALI) is the first low‐density lipoprotein (LDL)‐apheresis technique by which atherogenic LDL and lipoprotein(a) (Lp(a)) can be selectively removed from whole blood… Expand
A simultaneous study of the metabolism of apolipoprotein B and albumin in nephrotic patients.
BACKGROUND The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia and hyperlipidemia. Despite intensive research it is not clear at present what the causal links are between these… Expand
Ex vivo biocompatibility of avidin-agarose: a new device for direct adsorption of biotinylated antibodies from human whole blood.
- T. Bosch, A. Lennertz, C. Duhr, E. Fink, W. Samtleben
- Chemistry, Medicine
- Artificial organs
- 1 September 2000
Radioimmunotherapy using radiolabeled antitumor antibodies (RAA) is limited by the toxicity of unbound antibodies in the circulation. Removal of excessive antibodies by affinity-adsorption could… Expand
DALI apheresis in hyperlipidemic patients: biocompatibility, efficacy, and selectivity of direct adsorption of lipoproteins from whole blood.
Recently, the first apheresis technique for direct adsorption of low-density lipoprotein (LDL) and lipoprotein(a) [Lp(a)] from whole blood (DALI) was developed that does not require a prior plasma… Expand
LDL hemoperfusion--a new procedure for LDL apheresis: first clinical application of an LDL adsorber compatible with human whole blood.
To date, lipid apheresis procedures can remove low-density lipoprotein (LDL) cholesterol (LDL-C) only from plasma. Thus, initially plasma has to be separated from the blood cells, which increases the… Expand
Biocompatibility and clinical performance of a new modified cellulose membrane.
A new modified cellulose dialysis membrane (MC, 1.2 m2) in which less than 5% of cellulosic OH-groups are substituted by tertiary amino groups was tested in a 6-week clinical trial for… Expand
LDL hemoperfusion--a new procedure for LDL apheresis: biocompatibility results from a first pilot study in hypercholesterolemic atherosclerosis patients.
Current lipid apheresis techniques can remove atherogenic lipoproteins only from plasma. The initial mandatory separation of plasma and blood cells renders the extracorporeal circuit complex. We… Expand
Effect of protein adsorption on diffusive and convective transport through polysulfone membranes.
Effect of low-dose citrate anticoagulation on the clinical safety and efficacy of direct adsorption of lipoproteins (DALI apheresis) in hypercholesterolemic patients: a prospective controlled…
Direct adsorption of lipoproteins (DALI) is the first lipid apheresis system compatible with whole blood with the advantage of a very simple procedure. A mixture of heparin plus citrate (ACD-A) is… Expand
Therapeutic plasma exchange in the intensive care setting.
- W. Samtleben, N. Mistry-Burchardi, B. Hartmann, A. Lennertz, T. Bosch
- Therapeutic apheresis : official journal of the…
- 1 October 2001
The potential to treat life-threatening conditions with therapeutic plasma exchange (TPE) is limited to a few situations. In severe pulmonary hemorrhage as a complication of several immune disorders… Expand