T. Bosch

Publications245
h-index57
Citations13,001
Highly Influential Citations550
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The dynamic genome of Hydra
TLDR
Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann–Mangold organizer, pluripotency genes and the neuromuscular junction.
Animals in a bacterial world, a new imperative for the life sciences
TLDR
Recent technological and intellectual advances that have changed thinking about five questions about how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; and how is homeostasis maintained between animals and their symbionts are highlighted.
The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss
TLDR
Consideration of these patterns of gene distribution underscores the likely significance of gene loss during animal evolution whilst indicating ancient origins for many components of the vertebrate innate immune system.
Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis.
TLDR
The efficient generation of transgenic Hydra lines by embryo microinjection revealed remarkably high motility of individual endodermal epithelial cells during morphogenesis and is expected to become important tools to dissect the molecular mechanisms of development at the base of the Metazoan tree.
Regulation of Polyp-to-Jellyfish Transition in Aurelia aurita
More than just orphans: are taxonomically-restricted genes important in evolution?
Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration.
  • T. Bosch
  • Biology
    Developmental biology
  • 15 March 2007
Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra
  • S. Fraune, T. Bosch
  • Biology, Environmental Science
    Proceedings of the National Academy of Sciences
  • 7 August 2007
TLDR
The analysis suggests that the Hydra epithelium actively selects and shapes its microbial community, and strongly indicates distinct selective pressures imposed on and within the epithelia.
Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.
Defining the origins of the NOD-like receptor system at the base of animal evolution.
TLDR
First evidence that early diverging metazoans have large and complex NLR repertoires is provided, and induced proximity recruitment of an effector caspase to the HyNLR type 1 protein upon oligomerization indicates a potential role of casp enzyme activation downstream of NLR activation in Hydra.
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