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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitroExpand
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Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Long-term enhancement of synaptic efficacy in the hippocampus is an important model for studying the cellular mechanisms of neuronal plasticity, circuit reorganization, and even learning and memory.Expand
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Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation
The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However, the downstream pathways required to mediate these functions areExpand
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Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility that BDNF/TrkBExpand
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Morphological changes in dendritic spines associated with long-term synaptic plasticity.
Dendritic spines are morphological specializations that receive synaptic inputs and compartmentalize calcium. In spite of a long history of research, the specific function of spines is still not wellExpand
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Tuning and Topography in an Odor Map on the Rat Olfactory Bulb
The sense of smell originates in a diverse array of receptor neurons, comprising up to 1000 different types. To understand how these parallel channels encode chemical stimuli, we recorded theExpand
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Genesis of dendritic spines: insights from ultrastructural and imaging studies
Dendritic spines are small protrusions from many types of neuron, which receive most of the excitatory inputs to the cell. Spines are thought to have important roles in neural information processingExpand
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Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons and their synapses need to be studied in the intact brain over extended periods of time. Two-photonExpand
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Spatial Relationships among Three Columnar Systems in Cat Area 17
In the primary visual cortex, neurons with similar response properties are arranged in columns. As more and more columnar systems are discovered it becomes increasingly important to establish theExpand
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Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patterns
We use in vivo optical imaging based on intrinsic signals to gather information on the responses of a piece of cortex to gratings in many different orientations. Expand
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