• Publications
  • Influence
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
TLDR
It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal. Expand
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
TLDR
It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells. Expand
Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.
TLDR
It is shown that PRC2 activity is not only associated with H3K27me3 but also regulates all forms of H3k27 methylation in a spatially defined manner, contributing to different genomic functions in mouse embryonic stem cells. Expand
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.
TLDR
It is shown at a genome-wide level that Ogt preferentially associates with Tet1 to genes promoters in close proximity of CpG-rich transcription start sites, suggesting a link between Tet1 and Ogt activities in regulating C pG island methylation. Expand
The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells
TLDR
HMG1 has all the hallmarks of a molecule that can promote atherosclerosis and restenosis after vascular damage, and it is shown that HMG1 can be released by damage or necrosis of a variety of cell types, including endothelial cells. Expand
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.
TLDR
It is found that lysine methylation is absent prior to histone incorporation into chromatin, except at H3K9.3, and initial modifications impact final PTMs within chromatin. Expand
The HP1α–CAF1–SetDB1‐containing complex provides H3K9me1 for Suv39‐mediated K9me3 in pericentric heterochromatin
TLDR
It is shown that the histone H3K9 methyltransferase SetDB1 associates with the specific heterochromatin protein 1α (HP1α)–chromatin assembly factor 1 (CAF1) chaperone complex, which probably provides H 3K9me1 for subsequent trimethylation by Suv39H1/H2 in pericentric regions. Expand
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
TLDR
The characterization of the fungal metabolite chaetocin as the first inhibitor of a lysine-specific histone methyltransferase for SU(VAR)3-9 both in vitro and in vivo is reported. Expand
The double life of HMGB1 chromatin protein: architectural factor and extracellular signal
TLDR
The High Mobility Group Box (HMGB) chromosomal proteins have been known and studied for a long time, but they also have an extracellular function, which will be the prime focus of this short review. Expand
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry
TLDR
NPG Nature Asia-Pacific, 2-37 Ichigayatamachi, Shinjuku-ku, Tokyo 162-0843, Tel: 81 (03) 3267 8751, Fax: 81-03- 3267 8746. Expand
...
1
2
3
4
5
...