Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth
- M. O'Reilly, T. Boehm, J. Folkman
- 24 January 1997
Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR
- T. Boehm, S. Scheu, K. Pfeffer, C. Bleul
- BiologyJournal of Experimental Medicine
- 1 September 2003
It is shown that thymocytes and medullary epithelial cells (MECs) communicate via the lymphotoxin β receptor (LTβR) signaling axis, suggesting an unexpected role for LTβR signaling in central tolerance induction.
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
- T. Boehm, J. Folkman, T. Browder, M. O'Reilly
- Biology, MedicineNature
- 27 November 1997
It is shown that drug resistance does not develop in three tumour types treated with a potent angiogenesis inhibitor, and an unexpected finding is that repeated cycles of antiangiogenic therapy are followed by prolonged tumour dormancy without further therapy.
Human Immunoglobulin M Memory B Cells Controlling Streptococcus pneumoniae Infections Are Generated in the Spleen
- Stephanie Kruetzmann, M. Rosado, R. Carsetti
- Biology, MedicineJournal of Experimental Medicine
- 7 April 2003
The physiological and transient predisposition to pneumococcal infections of young children (0–2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM.
Two Genetically Separable Steps in the Differentiation of Thymic Epithelium
- M. Nehls, B. Kyewski, T. Boehm
- Biology, MedicineScience
- 10 May 1996
The WHN transcription factor was shown to be the product of the nude locus and these results define the first genetically separable steps during thymic epithelial differentiation.
Elephant shark genome provides unique insights into gnathostome evolution
- B. Venkatesh, Alison P. Lee, W. Warren
- 8 January 2014
The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.
MHC Class I Peptides as Chemosensory Signals in the Vomeronasal Organ
- Trese Leinders-Zufall, P. Brennan, T. Boehm
- 5 November 2004
It is shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor–expressing zone of the vomer onasal epithelium.
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
- C. Bleul, Tatiana Corbeaux, A. Reuter, P. Fisch, J. S. Mönting, T. Boehm
- 22 June 2006
In vivo cell lineage analysis in mice demonstrates the presence of a common progenitor of cortical and medullary TECs after birth, suggesting that cell-based therapies could be developed for thymus disorders.
Mate choice decisions of stickleback females predictably modified by MHC peptide ligands.
- M. Milinski, S. Griffiths, K. M. Wegner, T. Reusch, A. Haas-Assenbaum, T. Boehm
- BiologyProceedings of the National Academy of Sciences…
- 22 March 2005
It is suggested that female sticklebacks use evolutionarily conserved structural features of MHC peptide ligands to evaluate MHC diversity of their prospective mating partners.