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Eukaryotic cytosine methyltransferases.
TLDR
There are multiple families of DNA (cytosine-5) methyltransferases in eukaryotes, and each family appears to be controlled by different regulatory inputs.
The DNA methyltransferases of mammals.
  • T. Bestor
  • Biology
    Human molecular genetics
  • 1 October 2000
TLDR
The biological significance of 5-methylcytosine was in doubt for many years, but is no longer, and it has become clear that programmed changes in methylation patterns are less important in the regulation of mammalian development than was previously believed.
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
TLDR
DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2, and substitution of key residues in the binding site eliminated the H3 tail–DN MT3L interaction.
Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2
TLDR
The sequence and the structure of DNA methyltransferase-2 (DnMT2) bear close affinities to authentic DNA cytosine methyltransferases, and human DNMT2 protein restored methylation in vitro to tRNAAsp from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.
Dnmt3L and the Establishment of Maternal Genomic Imprints
TLDR
Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
TLDR
It is shown that DNA methyltransferase 3-like (Dnmt3L) is expressed in testes during a brief perinatal period in the non-dividing precursors of spermatogonial stem cells at a stage where retrotransposons undergo de novo methylation.
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