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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
- A. Zaki, S. van Boheemen, T. Bestebroer, A. Osterhaus, R. Fouchier
- Medicine, BiologyThe New England journal of medicine
- 7 November 2012
The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Mapping the Antigenic and Genetic Evolution of Influenza Virus
The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003 and offers a route to predicting the relative success of emerging strains.
Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets
Avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza.
A previously undescribed coronavirus associated with respiratory disease in humans.
- R. Fouchier, N. Hartwig, A. Osterhaus
- Biology, MedicineProceedings of the National Academy of Sciences…
- 20 April 2004
The identification and characterization of a not previously recognized coronavirus obtained from an 8-mo-old boy suffering from pneumonia is described, revealing that it is most closely related to porcine epidemic diarrhea virus and HCoV 229E.
Analysis of the genomic sequence of a human metapneumovirus.
The high percentage of sequence identity between APV and hMPV, their similar genomic organization (3'-N-P-M-F-M2-SH-G-L-5'), and phylogenetic analyses provide evidence for the proposed classification of h MPV as the first mammalian metapneumovirus.
Characterization of a Novel Influenza A Virus Hemagglutinin Subtype (H16) Obtained from Black-Headed Gulls
A previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gulls in Sweden, is described and proposed that sequence analyses of HA and NA genes of influenza A viruses be used for the rapid identification of existing and novel HA andNA subtypes.
Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
It is proposed that a novel human coronavirus isolated from a man with acute pneumonia and renal failure in June 2012 prototypes a novel species in the genus Betacoronavirus, which is closely related to bat coronaviruses that are distant from SARS-CoV.
Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture
- Adriaan H. de Wilde, D. Jochmans, E. Snijder
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 19 May 2014
Four compounds are identified inhibiting MERS-CoV replication in the low-micromolar range (50% effective concentrations [EC50s], 3 to 8 μM) and may offer a starting point for treatment of patients infected with zoonotic coronavirus infections.
Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.
- V. Corman, I. Eckerle, C. Drosten
- BiologyEuro surveillance : bulletin Europeen sur les…
- 27 September 2012
Two real-time reverse-transcription polymerase chain reaction assays for a novel human coronavirus, targeting regions upstream of the E gene (upE) or within open reading frame (ORF)1b, respectively, observed no cross-reactivity with coronaviruses OC43, NL63, 229E, SARS-CoV or with 92 clinical specimens containing common human respiratory viruses.
Detection of Influenza A Viruses from Different Species by PCR Amplification of Conserved Sequences in the Matrix Gene
- R. Fouchier, T. Bestebroer, S. Herfst, L. Van Der Kemp, G. Rimmelzwaan, A. Osterhaus
- BiologyJournal of Clinical Microbiology
- 1 November 2000
A new set of primers, based on highly conserved regions of the matrix gene, was designed for single-tube reverse transcription-PCR for the detection of influenza A viruses from multiple species, which proved to be fully reactive with a panel of 25 genetically diverse virus isolates that were obtained from birds, humans, pigs, horses, and seals.