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Differential regulation of Estrogen Receptor (ER)α and ERβ in primate mammary gland
TLDR
Control of gonadal hormone receptors during the menstrual cycle, pregnancy, and lactation in rhesus monkey mammary gland is reported on and it is found that ERα but not ERβ is down-regulated when E2 levels increase and when cells enter the cell cycle.
Chronic Respiratory Aeroallergen Exposure in Mice Induces Epithelial-Mesenchymal Transition in the Large Airways
TLDR
The results show the contribution of EMT to airway remodeling in chronic asthma-like inflammation and suggest that Th2-polarized airway inflammation can trigger invasion of epithelial cells into the subepithelial regions of the airway wall where they contribute to fibrosis, demonstrating a previously unknown plasticity of theAirway epithelium in allergic airway disease.
Synergistic Transactivation of the Differentiation-dependent Lung Gene Clara Cell Secretory Protein (Secretoglobin 1a1) by the Basic Region Leucine Zipper Factor CCAAT/Enhancer-binding Protein α and
TLDR
The results suggest that the cooperation of C/EBPα and Nkx2.1 is a major determinant for the high level, lung epithelial-specific expression of CCSP during the later stages of lung development and in the adult lung.
Glucocorticoids regulate the CCSP and CYP2B1 promoters via C/EBPbeta and delta in lung cells.
TLDR
In transient transfections of lung epithelial cells, glucocorticoids increased expression from the CCSP and CYP2B1 promoters and it was demonstrated that induction was dependent on the integrity of C/EBP-binding sites in both promoters.
Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium
TLDR
The data suggest that Gpr116 modulates endothelial properties, a previously unappreciated function despite the pan-vascular expression of this receptor, and describe a new role in the central nervous system vasculature.
Ectopic expression of C/EBPalpha in the lung epithelium disrupts late lung development.
TLDR
The results show a role for C/EBPalpha in lung development and suggest a function in the later stages of lung branching morphogenesis, and show the developmental expression of C/ EBPalpha, -beta, and -delta in the lung.
Airway epithelial cell differentiation during lung organogenesis requires C/EBPα and C/EBPβ
TLDR
It is demonstrated that C/EBPα and C/ EBPβ play pivotal, and partly overlapping roles in determining airway epithelial differentiation, with possible implications for tissue regeneration in lung homeostasis and disease.
Differential regulation of estrogen receptor (ER)alpha and ERbeta in primate mammary gland.
TLDR
Regulation of gonadal hormone receptors during the menstrual cycle, pregnancy, and lactation in rhesus monkey mammary gland and on the relationship of these receptors to proliferation are reported on.
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