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Comparison of the metabolism of 2,4-toluenediamine in rats and mice.
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than inExpand
Enzymic N-acetylation of 2,4-toluenediamine by liver cytosols from various species.
In hamsters and rabbits the highest N-acetyltransferase activity was present in the liver cytosol, followed by kidney intestinal mucosa and lung cytosols, and there was a slight difference in the levels of N- acetyltransferases in males and females. Expand
Mutagenicity of urine from rats after administration of 2,4-diaminoanisole: the effect of microsomal enzyme inducers.
The mutagenicity pattern for urine in vitro was shown to be similar with liver S9 from rats induced either with Aroclor 1254 or with MC, and the number of revertants was almost doubled in the presence of an activating system. Expand
Experimentally induced cancer of the colon in rats and mice.
Preparation and spectra of some acetyl derivatives of 2,4-toluenediamine
Table I . Physical Data, Yields, and Synthetic Conditions 2,4-Toluenediamine, an intermediate in polyurethane foam and elastomer production, has a carcinogenic effect in rats (2. 3, 6 ) .Expand
The metabolism of 6-aminochrysene in the rat.
Abstract The absorption, distribution and excretion of 6 -aminochrysene- 5 , 6 - 14 C were investigated in rats. The highest concentration of radioactivity in the organs at 48 hr after an i. p. doseExpand
Metabolism of the dyestuff intermediate 2,4-diaminoanisole in the rat.
1.2HCl administered intraperitoneally to rats is excreted chiefly via the urine (79 and 85% of the dose in 24 and 48 h, respectively) and the isotope in the faeces was 2,4-Diamino[ring-U-14C]anisole. Expand
Long-term effect of benzene in C57BL/6N mice.
A high incidence of amyloidosis developed in mice of all treated and untreated groups and in most exposed mice, and induced lymphomas or leukemias and intestinal tumors in a few. Expand