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A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells
Natural killer (NK) cell–mediated lysis is negatively regulated by killer cell inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules. In this study, weExpand
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The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA‐G1 and HLA‐E molecules co‐expressed on target cells
Previous studies on NK recognition of HLA‐G1 employed as targets 721.221 transfectants (.221‐G1) that unknowingly co‐expressed the HLA‐E molecule, subsequently found to be a major ligand for theExpand
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Identification and expression of two forms of the human transforming growth factor‐β‐binding protein endoglin with distinct cytoplasmic regions
Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor‐β (TGF‐β) and whose expression is up‐regulated on myeloid cells upon differentiation to macrophages. WeExpand
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HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis
HLA-A*31:01 was reported to be associated with carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCAR), including drug reaction with eosinophilia and systemic symptoms (DRESS),Expand
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NK cell recognition of non-classical HLA class I molecules.
NK cells recognize several HLA class Ib molecules employing both immunoglobulin-like (Ig-like) and C-type lectin receptors. The CD94/NKG2 and NKG2D lectin-like molecules, respectively, interact withExpand
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Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: a prospective study.
BACKGROUND Recent research shows that both pediatric and adult patients with eosinophilic esophagitis (EoE) experience esophageal remodeling marked by increased collagen deposition in which TGF-βExpand
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Mutational Analysis of Immunoreceptor Tyrosine-Based Inhibition Motifs of the Ig-Like Transcript 2 (CD85j) Leukocyte Receptor1
The inhibitory receptor Ig-like transcript (ILT)2 (leukocyte Ig-like receptor or CD85j) is a type I transmembrane protein expressed by different leukocyte lineages. The extracellular region of ILT2Expand
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The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules
CD94, a type II membrane protein containing a C‐type lectin domain, has been shown to be involved in natural killer (NK) cell‐mediated recognition of different HLA allotypes. The inhibitory form ofExpand
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Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization.
Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is a cell adhesion molecule involved in transendothelial migration and expressed by hemopoietic and endothelial cells. To understand theExpand
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Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules
Summary: A multigene family of immunoglobulin superfamily (Ig‐SF) killer cell inhibitory receptors (KIRs) specifically recognize HLA class I molecules, while the interaction with H‐2 products isExpand
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