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A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells
A novel inhibitory MHC class I receptor of the immunoglobulin-superfamily is characterized, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells, suggesting that diverse leukocyte lineages have adopted recognition of self–MHC class II molecules as a common strategy to control cellular activation during an immune response.
The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA‐G1 and HLA‐E molecules co‐expressed on target cells
It is demonstrated that NK recognition of cells expressing HLA‐G1 involves at least two non‐overlapping receptor‐ligand systems: the CD94/NKG2 interaction with HLA •E, and the engagement of the ILT2(LIR1) receptor by HLA•G1 molecules.
Identification and expression of two forms of the human transforming growth factor‐β‐binding protein endoglin with distinct cytoplasmic regions
Both forms were shown to bind TGF‐β1 and, when overexpressed in transfected mouse fibroblasts, to form disulfide‐linked homodimers, indicating that the cysteine residues present in the extracellular domain are responsible for the dimerization.
Spanish Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome.
The first Spanish guidelines on DRESS syndrome are now being published and important aspects as practical recommendations about clinical diagnosis, identification of the culprit drug through the Spanish pharmacovigilance system algorithm and allergy study have been addressed.
Regulated expression on human macrophages of endoglin, an Arg‐Gly‐Asp‐containing surface antigen
Immunostaining of frozen tissue sections with the 8E11 monoclonal antibody demonstrated the presence of endoglin not only in the endothelium of all the tissues studied, but also on the interstitial macrophages present in the red pulp of the spleen.
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis
It is found that HLA-A*31:01 is a specific predictor for CBZ-DRESS but not forCBZ-SJS/TEN in Europeans, and the cost-effectiveness of the combined Hla-A*,15:02 genetic test to prevent CBz-SCAR in Chinese needs further investigation.
NK cell recognition of non-classical HLA class I molecules.
NK cells recognize several HLA class Ib molecules employing both immunoglobulin-like (Ig-like) and C-type lectin receptors, and the KIR2DL4 (p49) receptor has been shown to specifically recognize HLA-G1.
The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules
It is demonstrated that the inhibitory receptor is in fact a complex formed by the covalent association of CD94 with the NKG2‐A molecule (Mr ∼ 43 kDa), another member of the C‐type lectin superfamily, and that Z199 mAb specifically recognize NKG 2‐A molecules.
Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules
Summary: A multigene family of immunoglobulin superfamily (Ig‐SF) killer cell inhibitory receptors (KIRs) specifically recognize HLA class I molecules, while the interaction with H‐2 products is