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PTEN-deficient intestinal stem cells initiate intestinal polyposis
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of theExpand
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Differential CC chemokine-induced enhancement of T helper cell cytokine production.
Chemokines are a family of small m.w. cytokines that induce chemotaxis and chemokinesis of leukocytes. These molecules are ligands for seven-transmembrane, Gi protein-linked receptors that induce aExpand
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Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined.Expand
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IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.
Astrocytes may serve as effectual APCs for T cell-mediated immune responses to myelin components during multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Although astrocytesExpand
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Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
Imbalance in the regulatory immune mechanisms that control intestinal cellular and bacterial homeostasis may lead to induction of the detrimental inflammatory signals characterized in humans asExpand
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Increased prevalence of gastroesophageal reflux symptoms in patients with COPD.
STUDY OBJECTIVES To determine the prevalence of gastroesophageal reflux (GER) symptoms in patients with COPD and the association of GER symptoms with the severity of airways obstruction as assessedExpand
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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Inflammatory bowel disease (IBD) is associated with mucosal T cell activation and diarrhea. We found that T cell activation with anti-CD3 mAb induces profound diarrhea in mice. Diarrhea wasExpand
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Functional differentiation of T cells in the intestine of T cell receptor transgenic mice.
The intestinal lamina propria (LP) is a major effector site of the mucosal immune system where antigen-specific and antigen-nonspecific factors shape the functional responses of CD4+ T helper cells.Expand
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Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells.
A novel monoclonal antibody, 2E7, was shown by immunoprecipitation to be reactive with the alpha IEL beta 7 integrin and was employed to analyze the expression of this integrin in lymphocyte subsetsExpand
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Efficacy and safety of tacrolimus in refractory ulcerative colitis and Crohn's disease: A single‐center experience
Background: The published experience regarding the use of tacrolimus in Crohn's disease (CD) and ulcerative colitis (UC) refractory to more commonly used medical therapy has been fairly limited. OurExpand
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