“Serendipity” in drug discovery implies the finding of one thing while looking for something else, and this was the case in six of the twelve serendipitous discoveries reviewed in this paper.Expand
Treatment with chlorpromazine focused attention on the heterogeneity of schizophrenia in terms of responsiveness to treatment, and by the mid-1980s there was sufficient evidence to believe that resolving this heterogeneity is a prerequisite for developing more effective treatments.Expand
CODE‐DD demonstrated the broadness of the DSM‐III‐R diagnosis of major depression and provided information for designing studies for the detection of the treatment responsive population of reboxetine.Expand
The paper concludes that resolving the heterogeneity of the schizophrenic population would open up a new perspective for genetic research and for the pharmacotherapy of the different illnesses covered up for a century by the diagnostic label of schizophrenia.Expand
Although one can no longer expect that 2 of 3 depressed patients will respond to treatment, the newer antidepressants are better tolerated, because they produce less anticholinergic side effects.Expand
Effective treatment of schizophrenia was achieved only after the introduction of antipsychotic drugs, in the 1950s, and is still progressing, according to this review.Expand
Treatment with therapeutically effective drugs of mania, schizophrenia, depression, bipolar disorder, generalized anxiety disorder, panic disorder, obsessive compulsive disorder, Alzheimer's disease, etc., during the second half of the 20th century brought to attention the heterogeneity of the populations within the diagnostic categories of schizophrenia and depression.Expand
It is concluded that the sexual behavior of the male schizophrenic provides an important forum for studying the interaction between psychological, sociological and biochemical-pharmacological factors which determine sexual behavior.Expand
Ces nouvelles hypotheses se fondent sur une nouvelle orientation de the pensee au sujet de the schizophrenie, provoquee par the chlorpromazine and l'introduction of the methode pharmacologique dans le traitement des problemes psychiat...Expand