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Increased expression of interleukin 17 in inflammatory bowel disease
Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum ofExpand
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Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II.
In our mutation analyses of bilirubin UDP glycosyltransferase (UGT1A1) gene, we encountered six patients with Crigler-Najjar syndrome type II who were double homozygotes for G71R and Y486D, a patientExpand
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Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line.
The barrier functions in epithelial and endothelial cells seem to be very important for maintaining normal biological homeostasis. However, it is unclear whether or how bile acids affect theExpand
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Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts.
BACKGROUND & AIMS We have previously isolated and characterized human pancreatic periacinar myofibroblasts. In this study, to define the role of these cells in the pathogenesis of acute pancreatitis,Expand
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Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.
We evaluated the effects of rat anti-mouse IL-17 neutralizing monoclonal antibody (mAb) on the development of dextran sulfate sodium (DSS)-induced colitis. Tissue samples were evaluated by standardExpand
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Regulation of PepT1 Peptide Transporter Expression in the Rat Small Intestine under Malnourished Conditions
Background and Aims: Many investigations suggested that peptide nutrition had a clinical advantage for nitrogen absorption. Recently, the cDNA encoding the H+/peptide cotransporter PepT1 was cloned.Expand
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Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial
Objectives Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We haveExpand
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Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
Dendritic cells (DCs) have been regarded as one of the effective antigen‐presenting cells, but the relationship between DCs and lymphocytes, in particular natural killer (NK) cells, remains unclear.Expand
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Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment.
: There is increasing evidence that intestinal microflora play an important role in the pathogenesis of ulcerative colitis. Therefore, modification of the microflora by prebiotics, probiotics, andExpand
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Enhancement of brush border membrane peptidase activity in rat jejunum induced by starvation
Abstract. Conflicting results have been obtained in previous studies concerning the adaptation of intestinal brush border membrane enzymes to starvation. This study was designed to clarify theExpand
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