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Polysaccharide-oligoamine based conjugates for gene delivery.
This work describes a versatile and universal polycation system based on oligoamines grafted on natural polysaccharides that is capable of complexing various plasmids and administering them intoExpand
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Current developments in gene transfection agents.
DNA can be delivered into the cell nucleus either using physical means or specific carriers that carry the genes into the cells for gene expression). Various carriers for delivering genes have beenExpand
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Synthesis and characterization of novel water soluble amphotericin B-arabinogalactan conjugates.
The coupling of amphotericin B (AmB), a water-insoluble antifungal agent, to arabinogalactan (AG) via an imine or amine bond was systematically investigated. AG was oxidized using potassiumExpand
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Novel dextran–spermine conjugates as transfecting agents: comparing water-soluble and micellar polymers
Recently, a novel cationic polymer, dextran–spermine (D–SPM) was developed for gene delivery. An efficient transfection was obtained using this polycation for a variety of genes and cell lines inExpand
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Dextran–spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfection
Dextran–spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate wasExpand
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Cationic Polysaccharides for Gene Delivery
Cationic polysaccharides based on spermine−dextran conjugates were synthesized and tested as vectors for gene transfection. Dextrans of 10−380 kDa were oxidized under mild conditions by potassiumExpand
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Hydrophobized dextran-spermine conjugate as potential vector for in vitro gene transfection.
Dextran polysaccharide was grafted by reductive-amination with mixtures of spermine and other natural/synthetic oligoamines of two to four amine groups. The transfection efficiencies of theExpand
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Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically.
In this study, we compared two systems which can be applied for transfection in vitro and in vivo: polyplexes based on the polymer dextran-spermine (D-SPM) and lipoplexes based onExpand
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Quaternary ammonium polysaccharides for gene delivery.
Cationic polysaccharides were synthesized by conjugation of various monoquaternary (MQ) ammonium oligoamines to oxidized dextran by reductive amination and tested for gene transfection. PolycationsExpand
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Dextran‐spermine conjugate: an efficient vector for gene delivery
Cationic Polysaccharides based on oligoamine-dextran conjugates were synthesized and tested as vectors for gene transfection. Dextran with 40 kDa in average molecular weight was oxidized under mildExpand
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