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Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State
TLDR
Gadd153 sensitizes cells to ER stress through mechanisms that involve down-regulation of Bcl2 and enhanced oxidant injury and protected cells from ER stress-induced cell death.
Reactive oxygen species, cellular redox systems, and apoptosis.
  • M. Circu, T. Aw
  • Biology
    Free radical biology & medicine
  • 15 March 2010
The regulation of hepatic glutathione.
TLDR
This work proposes to review some of the recent exciting developments in this field, with a particular focus on the regulation of hepatic GSH, a fairly ubiquitous substance in aerobic life forms and tissues and generally exists in millimolar concentrations.
Mitochondrial transmembrane potential and pH gradient during anoxia.
TLDR
The results indicate that retention of the protonmotive force is not due to utilization of ATP produced by glycolysis and suggest that mechanisms exist to preserve ion distribution during anoxia.
Glutathione and modulation of cell apoptosis.
  • M. Circu, T. Aw
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1 October 2012
Intestinal redox biology and oxidative stress.
  • M. Circu, T. Aw
  • Biology
    Seminars in cell & developmental biology
  • 1 September 2012
Glutathione-dependent protection against oxidative injury.
Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine.
  • T. Aw
  • Biology
    The American journal of clinical nutrition
  • 1 October 1999
TLDR
An overview of the cellular responses to oxidative stress and oxidation-reduction imbalance and the role of NF-kappaB in these responses is provided and the current strategies used to study NF- kappaB activation and nuclear translocation are summarized, particularly in relation to dietary oxidant-mediated pathophysiology of the intestine.
Differential Effects of Superoxide Dismutase Isoform Expression on Hydroperoxide-induced Apoptosis in PC-12 Cells*
TLDR
A role for mitochondrial ROS in TBH-induced PC-12 apoptosis is supported that is attenuated by Mn-SOD overexpression and is independent of cellular GSH levelsper se.
Programmed cell death induced by ischemia-reperfusion in rat intestinal mucosa.
TLDR
Apoptosis in rat small intestine was induced by ischemia of the gut, and this process was exacerbated by reperfusion, and the changes in apoptosis were independent of ODC activity.
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