• Publications
  • Influence
Redox-Sensitive Transcription Factor Nrf2 Regulates Vascular Smooth Muscle Cell Migration and Neointimal Hyperplasia
TLDR
The findings suggest that the Nrf2 system is important for PDGF-stimulated vascular smooth muscle cell migration by regulating reactive oxygen species elimination, which may contribute to neointimal hyperplasia after vascular injury. Expand
Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages.
TLDR
The present findings suggest that HO-1 is induced via NO-induced nuclear translocation of Nrf2, and the enzymatic function ofHO-1 inhibits the overproduction of NO in macrophages. Expand
IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury.
TLDR
Insight is provided into IQGAP1 as a potential therapeutic target for vascular migration-related diseases through interaction with PDGFR and FA signaling proteins, which may contribute to VSMC migration and neointimal formation after injury. Expand
Unexpected Role of the Copper Transporter ATP7A in PDGF-Induced Vascular Smooth Muscle Cell Migration
TLDR
It is suggested that ATP7A plays an important role in copper-dependent PDGF-stimulated VSMC migration via recruiting Rac1 to lipid rafts at the leading edge, as well as regulating LOX activity, which may contribute to neointimal formation after vascular injury. Expand
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.
TLDR
It is demonstrated that IL-1alpha andIL-1beta are positive regulators for the Cyp7a1 gene in steady-state mice and that Cyp7 a1 is one of the factors that mediate the difference in serum total cholesterol level between sexes. Expand
Measurement of rate constants for quenching singlet oxygen with a Cypridina luciferin analog (2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo [1,2-a]pyrazin-3-one) and sodium azide.
TLDR
The rate constants for 1O2 [MCLA] and [1O2] [NaN3] were measured by quenching the near-infrared emission (1 delta g----3 sigma g) in steady state with MCLA and NaN3, respectively by measuring the rate constants of the O(2-) + MCLA reaction. Expand
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
TLDR
It is shown that IL-6 and TNFalpha are likely to be major factors involved in the down-regulation of CYP3A11 and 2C29 mRNAs in mice, and there exist differences in the amount and/or kind of cytokines released by BCG or LPS, the latter being more potent than the former. Expand
Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury
TLDR
It is reported that 14 days after arterial injury in mice, TUNEL-positive VSMCs are detected in both the neointimal and medial layers, and simultaneous Nrf2 depletion inhibits Keap1 depletion-induced apoptosis. Expand
Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1.
TLDR
The present findings suggest that auranofin is effective in preventing cocaine-induced hepatic injury, and HO-1 may contribute to protect against chemically-induced cytotoxicity. Expand
Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury
TLDR
Atox1 expression is upregulated in injured vessel, and it is colocalized with the Cu transporter ATP7A, one of the downstream targets of Atox1, mainly in neointimal VSMCs at day 14 after wire injury, which is a potential therapeutic target for VSMC migration and inflammation-related vascular diseases. Expand
...
1
2
3
4
5
...