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Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.
TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation. Expand
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
TLDR
It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death. Expand
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
TLDR
This review explores the etiology and pathogenesis of ischemic stroke, and provides a general model of such, and explores new and emerging approaches for the prevention and treatment of stroke. Expand
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
TLDR
It is demonstrated that, in both insulin-deficient rats and insulin-resistant mice, diabetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesis, and the adrenal steroid corticosterone contributes to these adverse effects. Expand
Role of T lymphocytes and interferon-gamma in ischemic stroke.
TLDR
It is indicated that CD4+ and CD8+ T lymphocytes, but not B lymphocyte, contribute to the inflammatory and thrombogenic responses, brain injury, and neurological deficit associated with experimental stroke. Expand
Toll-like receptors in neurodegeneration
TLDR
A better understanding of the molecular and cellular biology of TLRs in the normal and diseased nervous system, may lead to novel approaches for preventing neuronal degeneration and promoting recovery of function in an array of neurodegenerative conditions. Expand
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
TLDR
Evidence is provided that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke, and that IVIg treatment can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that targetinflammasome assembly and activity. Expand
Evidence that nucleocytoplasmic Olig2 translocation mediates brain‐injury‐induced differentiation of glial precursors to astrocytes
TLDR
Data indicate that the prompt maturation of numerous Olig2+ glial progenitors to astrocytes underlies the repair process after a traumatic injury, in contrast to neural stem cells and neuronal progenitor cells, which appear to play only a minor role in the injured adult CNS. Expand
Role of T Lymphocytes and Interferon-γ in Ischemic Stroke
TLDR
Findings indicate that CD4+ and CD8+ T lymphocytes, but not B lymphocyte, contribute to the inflammatory and thrombogenic responses, brain injury, and neurological deficit associated with experimental stroke. Expand
TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY
TLDR
The contribution of TLR activation in hepatic, renal, cerebral, intestinal, and myocardial I/R injuries is discussed and the development of specific TLR-targeted therapeutics to treat these conditions is discussed. Expand
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