• Publications
  • Influence
Pharmacokinetics and tissue distribution in animals of gadobenate ion, the magnetic resonance imaging contrast enhancing component of gadobenate dimeglumine 0.5 M solution for injection (MultiHance).
TLDR
Gadobenate dimeglumine combines the properties of an extracellular-fluid agent with those of a hepatobiliary agent and its complete elimination and biological stability satisfy the requirements for its safe use in humans.
High-performance liquid chromatographic assay of the magnetic resonance imaging contrast agent gadobenate in plasma, urine and bile.
TLDR
An HPLC method for assaying gadobenate (Gd-BOPTA2-) in plasma, urine and bile samples is described and the mean accuracy and precision of the method were in the range -3.4 to +5.5%, respectively.
High-performance liquid chromatographic assay of the X-ray contrast agent iopiperidol in plasma and urine of rats and humans.
TLDR
An HPLC method based on the reversed-phase chromatographic separation of iopiperidol and the internal standard from the endogenous components of the biological fluids, and their detection by UV absorption at 244 nm was satisfactory.
High-performance liquid chromatographic determination of the magnetic resonance imaging contrast agent gadobenate ion in plasma, urine, faeces, bile and tissues.
TLDR
An HPLC method based on the reversed-phase chromatographic separation of gadobenate ion from the endogenous components of biological matrices and detection by UV absorption at 210 nm was satisfactory and the selectivity was satisfactory.
High-performance liquid chromatographic determination of the X-ray imaging contrast agent, iofratol, in plasma and urine.
Iofratol is currently under evaluation as a potential X-ray contrast medium for angiography and myelography. An HPLC method for assaying iofratol in rat and human plasma and urine samples is