• Publications
  • Influence
Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement.
The present study was conducted to evaluate the validity and reproducibility of noninvasive brachial-ankle pulse wave velocity (baPWV) measurements and to examine the alteration of baPWV in patients
Staging of Argyrophilic Grains: An Age‐Associated Tauopathy
The study confirms that dementia with grains is an age-associated tauopathy with relatively uniform distribution and may independently contribute to cognitive decline in the elderly and propose the following staging paradigm.
Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects.
Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females, and baPWV was lower in females than in males until age 60, and became similar in both genders over age 60.
Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk.
The measurement of brachial-ankle pulse wave velocity (baPWV) is simple and applicable for general population studies. The present study was conducted to evaluate the applicability of baPWV for
Lewy body-related alpha-synucleinopathy in aging.
The findings indicate that LBs are associated with cognitive decline, either independently or synergistically with neurofibrillary tangles and senile plaques, and suggests a gender-specific risk factor.
Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan.
Investigation of the relationship between lung cancer cases in Japan and variant alleles of cytochrome P450 2A6 (CYP2A6*4*4), CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1 polymorphisms indicates that CYP1A6 deletions may be associated with lung cancer in the Japanese population studied.
Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study.
It is found that rs11614913 and rs2910164 do not pose general cancer risk, but rs116 14913 may influence gastric cancer in Japanese elderly population.
Lewy Body Pathology Involves Cutaneous Nerves
It is demonstrated for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases.
Accumulation of phosphorylated alpha-synuclein in aging human brain.
The findings suggest that LB-related pathology initially involves the neuronal perikarya, dendrites, and axons, causes impairment of axonal transport and synaptic transmission, and later leads to the formation of LBs, a hallmark of functional disturbance long before neuronal cell death.
Telomere lengths are characteristic in each human individual
Telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals.