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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouseExpand
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Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Induced pluripotent stem (iPS) cells can be generated from somatic cells by the introduction of Oct3/4 (also known as Pou5f1), Sox2, Klf4 and c-Myc, in mouse and in human. The efficiency of thisExpand
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Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
Anacardic acid attenuates mutant TDP-43–associated abnormalities in motor neurons derived from ALS patient–specific induced pluripotent stem cells. A Stepping Stone to ALS Drug Screening AmyotrophicExpand
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Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four transcription factors. However, the cell origins and molecularExpand
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Variation in the safety of induced pluripotent stem cell lines
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNSExpand
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Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated inducedExpand
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Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
Hepatocytes generated from human induced pluripotent stem cells (hiPSCs) are unprecedented resources for pharmaceuticals and cell therapy. However, the in vitro directed differentiation of humanExpand
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Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
A method for stimulating the differentiation of human pluripotent stem cells into kidney lineages remains to be developed. Most cells in kidney are derived from an embryonic germ layer known asExpand
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Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes
Pluripotent stem cells can be established by various methods, but they share several cytological properties, including germ cell differentiation in vitro, independently of their origin. AlthoughExpand
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Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products.
The regulation of human cell therapy products is a key factor in their development and use to treat human diseases. In that regard, there is a recognized need for a global effort to develop a set ofExpand
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