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Pharmacokinetics and efficacy of ropivacaine continuous wound instillation after joint replacement surgery.
TLDR
Infiltration and wound instillation with ropivacaine 0.2% is more effective in controlling postoperative pain than systemic analgesia after major joint replacement surgery.
Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release
  • G. Mereu, M. Fà, V. Cuomo
  • Biology, Psychology
    Proceedings of the National Academy of Sciences…
  • 4 April 2003
TLDR
The memory impairment caused by the gestational exposure to WIN was correlated with alterations of hippocampal long-term potentiation (LTP) and glutamate release, which could provide an explanation of cognitive alterations observed in children born from women who use marijuana during pregnancy.
The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus
TLDR
Modafinil may increase excitatory glutamatergic transmission in these regions, altering the balance between glutamate and GABA transmission, and be associated with a lack of effect on GABA release.
The Pharmacokinetics and Efficacy of Ropivacaine Continuous Wound Instillation After Spine Fusion Surgery
TLDR
Wound infiltration and continuous instillation of ropivacaine 0.2% is effective for pain management after spine stabilization surgery and the length of hospital stay was shorter in the R group.
Prenatal exposure to the CB1 receptor agonist WIN 55,212-2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring.
TLDR
Evidence is provided for a deficit in cortical glutamatergic neurotransmission and behaviour in the rat neonate following prenatal exposure to WIN and it is suggested that the reduction in cortical glutamate levels, NMDA receptor activity and alterations in neuronal development might underlie, at least in part, the learning deficit and decreased emotional reactivity observed in the offspring.
The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study.
TLDR
In vivo and in vitro findings suggest an increase in cortical glutamatergic transmission by CB(1) receptors, an effect that may underlie some of the psychoactive and behavioural actions of acute exposure to marijuana.
Effects of sarizotan on the corticostriatal glutamate pathways
TLDR
The findings suggest that the antidyskinetic properties of sarizotan could be mediated via its 5‐HT1A agonist actions in the motor cortex, leading to reduced activity in the corticostriatal glutamate pathways with reduced activation of the striatopallidal GABA pathway mediating motor inhibition.
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