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Control of NaCl transport in the thick ascending limb.
Evidence is presented for a model of NaCl absorption in the thick ascending limb in which net Cl- absorption is rheogenic and involves a secondary active transport process.
NaCl transport in mouse medullary thick ascending limbs. I. Functional nephron heterogeneity and ADH-stimulated NaCl cotransport.
The ion substitution and inhibitor data are consistent with the view that NaCl absorption in the mTALH depends on a secondary active transport process: NaCl entry across luminal membranes is a coupled process of indeterminate stoichiometry that is driven by the transmembrane electrochemical gradient for Na+, which is maintained by Na+-K+-ATPase.
Ischemic heart disease in patients with uremia undergoing maintenance hemodialysis.
The rate of IHD in dialysis women was greater than it was in nondialysis subjects, and coronary artery disease only affected long-term survival of patients with preexisting disease; and autopsy data did not suggest accelerated atherosclerosis.
Transforming growth factor β contributes to progressive diabetic nephropathy
Progress is being made in the understanding of the pathogenesis of diabetic renal disease and in the ability to delay, or even prevent, this devastating complication, according to this issue of PNAS.
Transforming growth factor beta contributes to progressive diabetic nephropathy.
Significant evidence to date is provided for the causal role of TGF-b in the structural and functional abnormalities of diabetic nephropathy and the ability to delay, or even prevent, this devastating complication of diabetes.
The Effect of Amphotericin B on the Water and Nonelectrolyte Permeability of Thin Lipid Membranes
These data were compatible with the hypothesis that the interactions of amphotericin B with membrane-bound cholesterol result in the formation of pores whose equivalent radii are in the range 7 to 10 A, with the effective hydrodynamic radii of the solutes tested.
About Kidney International.
The Interaction of Polyene Antibiotics with Thin Lipid Membranes
Data suggest that amphotericin B or nystatin may interact with membrane-bound sterols to produce multimolecular complexes which greatly enhance the permeability of such membranes for anions, acetate, and, to a lesser degree, cations (Na+, K+, Li+).