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Controlled, prospective trial of steroid treatment in IgA nephropathy: a limitation of low-dose prednisolone therapy.
BACKGROUND No accepted therapy has been established for progressive immunoglobulin A (IgA) nephropathy. METHODS A prospective, randomized, controlled trial of low-dose prednisolone therapy wasExpand
Comparison of endoscopic findings with symptom assessment systems (FSSG and QUEST) for gastroesophageal reflux disease in Japanese centres
Background and Aim:  We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for theExpand
Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis
Background and Aims:  MicroRNA (miRNA) are endogenous, approximately 22‐nucleotide non‐coding RNA that suppress gene expression at post‐transcriptional levels by binding to the 3′‐untranslated regionExpand
Bone marrow stromal cells, preadipocytes, and dermal fibroblasts promote epidermal regeneration in their distinctive fashions.
Mesenchymal cell types, under mesenchymal-epithelial interaction, are involved in tissue regeneration. Here we show that bone marrow stromal cells (BMSCs), subcutaneous preadipocytes, and dermalExpand
Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan
BackgroundsThe present study sought to establish a standard third-line eradication regimen for Helicobacter pylori in Japan.MethodsSubjects were 204 patients with H. pylori infection in whom theExpand
Comparison of the efficacy of granulocyte and monocyte/macrophage adsorptive apheresis and leukocytapheresis in active ulcerative colitis patients: a prospective randomized study
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with recurring inflammation of the colorectal mucosa. Recently, cytapheresis has emerged as a new treatment forExpand
Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection
It has been reported that polymorphisms of human leukocyte antigen (HLA) genes and several cytokine genes are associated with an increased risk of developing gastric cancer (GC). However, the resultsExpand
Helicobacter pylori in the palatine tonsils of patients with IgA nephropathy compared with those of patients with recurrent pharyngotonsillitis.
Helicobacter pylori infection is acquired by oral ingestion. However, the morphology and microscopic localization of H pylori in the human oral cavity and pharynx are unknown. In the present study,Expand
High incidence of idiopathic nephrotic syndrome in East Asian children: a nationwide survey in Japan (JP-SHINE study)
BackgroundLittle is known regarding the epidemiology of idiopathic nephrotic syndrome (INS) in East Asia. Previous studies have suggested higher incidence of INS in Asian children, though decreasingExpand
Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells.
It remains to be clarified whether adoptive cellular therapy (ACT) in patients with advanced cancer, in whom strong immunosuppression and immune-escape mechanisms are established, has the potentialExpand