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Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium. 2. Isolation and structural elucidation.
A novel antifungal antibiotic, haliangicin, was isolated from a culture broth of marine myxobacterium, Haliangium luteum. The planar structure of haliangicin was elucidated by spectroscopic analysesExpand
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Allergens from Dermatophagoides mites with chymotryptic activity
A new set of allergens from Dermatophagoides pteronyssinus and D. farinae (provisionally named DPS and DF5, respectively) was isolated from the whole culture of mites. The apparent molecular weightsExpand
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FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S. The compound inhibitedExpand
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A novel bone resorption inhibitor, A-75943 isolated from Streptomyces sp. SANK 61296.
A novel bone resorption inhibitor, A-75943, was isolated from Streptomyces sp. SANK 61296. Its structure was determined to be (1"S,2'R,3"S,4S',5"S)-2-[(3",5"-Expand
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Trypsin‐like protease of mites: purification and characterization of trypsin‐like protease from mite faecal extract Dermatophagoides farinae. Relationship between trypsin‐like protease and Der f III
A serine protease from mite faecal extract, Dermatophagoides farinae, was purified using DEAE‐Sephacel anion exchange chromatography and Supcrdex 75 pg gel chromato‐graphy. The molecular weight ofExpand
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Isolation of cysteine protease in the crude mite extract, Dermatophagoides farinae.
In order to study the relationship between cysteine protease and Der f I, which is one of the major allergens in the mite, Dermatophagoides farinae, isolation of cysteine protease was attempted usingExpand
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Specific measurement of a major mite allergen, Der f II, by an enzyme-linked immunosorbent assay system using monoclonal anti-Der f II antibodies.
An enzyme linked immunosorbent assay system using a monoclonal antibody, 15E11, specific for a major allergen Der f II in house dust mite, was developed. This system detected only Der f II in theExpand
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Specific reaction of α,β‐unsaturated carbonyl compounds such as 6‐shogaol with sulfhydryl groups in tubulin leading to microtubule damage
6‐Shogaol and 6‐gingerol are ginger components with similar chemical structures. However, while 6‐shogaol damages microtubules, 6‐gingerol does not. We have investigated the molecular mechanism ofExpand
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Cloning and sequencing of cDNAs corresponding to mite major allergen Der f II.
A cDNA library corresponding to mite protein was screened employing anti-Der f II antibody. Two possible clones were obtained, which contained plasmids, pFL1 and pFL11, respectively. Both plasmidsExpand
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