• Publications
  • Influence
Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures.
Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of TrichodermaExpand
Unusual C25 steroids produced by a sponge-derived Penicillium citrinum.
Two structurally unique steroids were isolated from the extract of a saltwater culture of sponge-derived Penicilliun citrinum and showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans. Expand
A chemical study of cyclic depsipeptides produced by a sponge-derived fungus.
Two novel cyclic depsipeptides A and B, together with a new destruxin derivative were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus, and showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans. Expand
Structure revision of spiroleucettadine, a sponge alkaloid with a bicyclic core meager in H-atoms.
The revised structure of spiroleucettadine is presented, a bicyclic sponge alkaloid with a scarcity of H-atoms in its core and reinforced the validity of DFT calculations in structure elucidation. Expand
Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties.
Insight on the biogeographical and phenotypic variations of Cacospongia mycofijiensis is presented that will enable a future study of the biosynthetic pathway that produces the fijianolides. Expand
Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria.
Saltwater culture of Myrothecium verrucaria was a source of three new trichothecenes, 3-hydroxyroridin E, 13'-acetyltrichoverrin B, and miophytocen C and nine known related compounds, which showed significant cytotoxicity against murine and human tumor cell lines. Expand
Biostructural features of additional jasplakinolide (jaspamide) analogues.
The objective of this study was to reinvestigate a Fijian collection of J. splendens in an effort to find jasplakinolide congeners with similar biological properties and the results of a clonogenic dose-response study on jas Plakolide are presented. Expand
Expanding the strategies in natural product studies of marine-derived fungi: a chemical investigation of penicillium obtained from deep water sediment.
Three previously unknown pentaketides, (+)-formylanserinone B, (-)-epoxyserinones A and B, along with two known fungal pigments, anserinones B and A, were isolated and identified from a deep water, marine-derived saltwater fungal culture. Expand
Four Classes of Structurally Unusual Peptides from Two Marine-Derived Fungi: Structures and Bioactivities.
The structures and biological properties of peptides produced by two genera of marine-derived fungi, an atypical Acremonium sp., and a Metarrhizium sp. were explored. The Acremonium strain wasExpand
Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.
This study involved a campaign to isolate and study additional latrunculin analogues from two taxonomically unrelated sponges, Cacospongia mycofijiensis and Negombata magnifica, and the cytotoxicities against both murine and human cancer cell lines were significant. Expand