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Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group.
TLDR
The beneficial effects of the EPA+GLA diet on pulmonary neutrophil recruitment, gas exchange, requirement for mechanical ventilation, length of intensive care unit stay, and the reduction of new organ failures suggest that this enteral nutrition formula would be a useful adjuvant therapy in the clinical management of patients with or at risk of developing ARDS. Expand
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
TLDR
GSK2586881 was well-tolerated in patients with ARDS, and the rapid modulation of RAS peptides suggests target engagement, although the study was not powered to detect changes in acute physiology or clinical outcomes. Expand
The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly
TLDR
The difficulties in differentiating asthma from COPD in current or former smokers are underscored, the institutional experience with overlap syndrome is shared, and the need for new research to better characterize and investigate this important clinical phenotype is highlighted. Expand
Tramadol Exposures Reported to Statewide Poison Control System
TLDR
Tramadol overdoses frequently cause CNS depression, nausea/vomiting, tachycardia, and seizures, and symptoms generally resolve within 24 hours, primarily causing sedation. Expand
The asthma–chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations
TLDR
The authors discuss the array of existing and emerging classes of drugs that could benefit those with ACOS and share their therapeutic approach. Expand
From vital signs to clinical outcomes for patients with sepsis: a machine learning basis for a clinical decision support system
TLDR
This study introduces a new scheme for the prediction of lactate levels and mortality risk from patient vital signs and WBC that can drive the appropriate response by clinical staff and thus may have important implications for patient health and treatment outcome. Expand
A review of current and novel therapies for idiopathic pulmonary fibrosis.
TLDR
The fibrosis in IPF is increasingly understood to be the result of a fibroproliferative and aberrant wound healing cascade, and the development of therapeutic targets has shifted in accord with this paradigm change. Expand
Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial
TLDR
Primary and retrospective analyses of efficacy suggest that treatment with rhIL-1ra results in a dose-related increase in survival time among patients with sepsis who have organ dysfunction and/or a predicted risk of mortality of 24% or greater. Expand
Methamphetamine and the expanding complications of amphetamines.
TLDR
Clinicians should be familiar with methamphetamine's medical effects and toxicity and with treatment options for acute and long-term effects of methamphetamine abuse. Expand
Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1).
TLDR
A practical application of the receptor-based screen developed here with RyR1 is that it provides a quantitative SAR that may be useful in predicting biological activity and risk of mixtures containing noncoplanar PCB congeners that have low or a lack of aryl hydrocarbon receptor activity. Expand
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