• Publications
  • Influence
A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity
TLDR
It is shown that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0(C) neurons, that represents the sole source of C bouton inputs to motor neurons, suggesting a role in the modulation of motor neuron firing frequency. Expand
V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during Walking
TLDR
It is proposed that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord and ensuring a symmetrical pattern of locomotor activity during walking. Expand
Descending command systems for the initiation of locomotion in mammals
TLDR
5-HT neurons located in the parapyramidal region (PPR) constitute the first anatomically discrete group of spinally-projecting neurons demonstrated to be involved in the initiation of locomotion in mammals, and it is concluded that the PPR is the source of a descending 5-HT command pathway that activates the CPG via 7-HT(7) and 5- HT(2A) receptors. Expand
Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration
TLDR
In ALS model mice expressing mutant superoxide dismutase (SOD1), reduction of MMP-9 function using gene ablation, viral gene therapy, or pharmacological inhibition significantly delayed muscle denervation and defined M MP-9 as a candidate therapeutic target for ALS. Expand
Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster
TLDR
Surprisingly, it is found that inactivation of sensory neurons in the fly's legs, to block proprioceptive feedback, led to deficient step precision, but interleg coordination and the ability to execute a tripod gait were unaffected. Expand
Patterns of Spinal Sensory-Motor Connectivity Prescribed by a Dorsoventral Positional Template
TLDR
It is shown that the final pattern of sensory-motor connections is initiated by the projection of sensory axons to discrete dorsoventral domains of the spinal cord without regard for motor neuron subtype or, indeed, the presence of motor neurons. Expand
Degradation of mouse locomotor pattern in the absence of proprioceptive sensory feedback
TLDR
It is found that locomotor pattern degrades upon elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs, establishing a role for proprioception feedback in the control of fundamental aspects of mammalian locomotor behavior. Expand
Neural Control of Unloaded Leg Posture and of Leg Swing in Stick Insect, Cockroach, and Mouse Differs from That in Larger Animals
TLDR
Size-dependent variations in whether legs have constant, gravity-independent postures, in whether swing motor neurons fire throughout the entirety of swing, and calculations of how quickly passive muscle force would slow limb movement as limb size varies suggest that these differences may be caused by scaling. Expand
Behavioral and electromyographic characterization of mice lacking EphA4 receptors.
TLDR
The data give the first detailed description of the locomotor behavior of an adult mouse with genetically manipulated spinal networks, suggesting an influence of sensory feedback in shaping the pattern of muscle activity during locomotion in the mutant animals. Expand
The role of sensory signals from the insect coxa-trochanteral joint in controlling motor activity of the femur-tibia joint.
TLDR
Experiments showed that fCS activity plays an important role in generating tibial motoneuron activity during the stance phase of walking, and suggested that sensory signals from the CT joint only weakly affect central rhythm-generating networks of the FT joint. Expand
...
1
2
3
4
5
...